https://scholars.lib.ntu.edu.tw/handle/123456789/570313
標題: | Central ossifying fibroma: A clinicopathologic study of 28 cases | 作者: | Chang C.-C. Hung H.-Y. JULIA YU-FONG CHANG Yu C.-H. YI-PING WANG Liu B.-Y. CHUN-PIN CHIANG |
公開日期: | 2008 | 出版社: | Scientific Communications International Ltd | 卷: | 107 | 期: | 4 | 起(迄)頁: | 288-294 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: Central ossifying fibroma (COF) is the most common benign fibro-osseous lesion of the jaw. This retrospective study evaluated the clinical and histopathologic features of 28 COFs in Taiwanese patients. Methods: Twenty-eight consecutive cases of COF were collected from 1988 to 2006. The clinical data and microscopic features of these cases were reviewed and analyzed. Results: The mean age of patients at the time of diagnosis was 34 years. There were six male and 22 female patients. Twenty-six (93%) cases were found in the mandible and two (7%) in the maxilla. The most common sites for COFs were the molar region (17 cases, 61%), followed by the premolar (8 cases, 28%), and incisor/canine (3 cases, 11%) regions. Bone swelling or expansion (96%, 26/27) was the most frequent clinical presentation. Six (21%) COFs presented as a radiolucent lesion, 17 (61%) as a mixed lesion, and five (18%) as a radio-opaque lesion. No recurrence of the lesion was found after surgical excision in this series. Microscopically, COFs showed trabeculae of woven bone (25 cases) and/or lamellar bone (5 cases) and/or spherules of cementoid (19 cases) in a cellular fibrous connective tissue stroma. The stromal component was highly cellular in 21 cases, moderately cellular in seven cases, prominently vascular in 11, and collagenous in six. Conclusion: COFs occur more frequently in female patients and in those in the second to fourth decades of life. The most commonly affected site is the mandible, especially the molar region. The majority of COF lesions present as a well-defined, mixed lesion radiographically. Most COFs can be treated by conservative surgical excision without subsequent recurrence. ? 2008 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-43449110080&doi=10.1016%2fS0929-6646%2808%2960089-3&partnerID=40&md5=68a430a79fbab65ea8954cd809b38c89 https://scholars.lib.ntu.edu.tw/handle/123456789/570313 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(08)60089-3 | SDG/關鍵字: | adult; article; bone pain; bone resection; bone swelling; cancer localization; canine tooth; clinical article; clinical feature; connective tissue; female; histopathology; human; human tissue; incisor; male; mandible cancer; mandible resection; maxilla cancer; maxilla resection; microscopy; molar tooth; ossifying fibroma; periodontics; premolar tooth; retrospective study; sex difference; tooth radiography; trabecular bone; tumor biopsy; tumor volume |
顯示於: | 臨床牙醫學研究所 |
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