https://scholars.lib.ntu.edu.tw/handle/123456789/570317
標題: | HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas | 作者: | Yu C.-H. Chen H.-H. Liu C.-M. YUNG-MING JENG Wang J.-T. YI-PING WANG Liu B.-Y. ANDY SUN CHUN-PIN CHIANG |
公開日期: | 2005 | 卷: | 34 | 期: | 9 | 起(迄)頁: | 540-545 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | BACKGROUND: Primary mucosal melanomas (MMs) of the head and neck are a rare entity. Melanomas with characteristic melanin-pigmented tumor cells are easy to diagnose, but those without melanin-pigmented tumor cells, amelanotic melanomas, are difficult to identify and need immunohistochemistry (IHC) to confirm the final diagnosis. In this study, we examined the expression of three melanocytic differentiation markers, HMB-45, S-100, and Melan-A in primary oral and nasal MMs. We tried to evaluate whether HMB-45, S-100, and Melan-A were useful for diagnosis of primary oral and nasal MMs and to find out which marker was the best of the three. METHODS: This study used IHC to examine the expression of HMB-45, S-100, and Melan-A in 17 formalin-fixed paraffin-embedded specimens of primary oral and nasal MMs. The staining intensities (SIs) and labeling indices (LIs) of HMB-45, S-100, and Melan-A in 17 MMs were calculated and compared between any two markers. RESULTS: Immunostaining results showed that the positive rate was 94% (16 of 17) for HMB-45, 88% (15 of 17) for S-100, and 71% (12 of 17) for Melan-A in 17 MMs. The SI of HMB-45 was significantly higher than that of S-100 (P = 0.0011) or of Melan-A (P = 0.0034). In addition, the mean LI of Melan-A (59 ± 43%) was significantly lower than that of HMB-45 (83 ± 28%, P = 0.0065) or of S-100 (79 ± 33%, P = 0.0237). CONCLUSIONS: Our results indicate that both HMB-45 and S-100 show a high positive rate and LI in MMs and therefore may be good markers for immunohistochemical diagnosis of primary oral and nasal MMs. In addition, HMB-45 may be a more sensitive marker than S-100 because HMB-45 shows a significantly higher SI than S-100 in this study. ? Blackwell Munksgaard 2005 · All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-25144506562&doi=10.1111%2fj.1600-0714.2005.00340.x&partnerID=40&md5=9644cdbf2343c962b4fae05800747729 https://scholars.lib.ntu.edu.tw/handle/123456789/570317 |
ISSN: | 0904-2512 | DOI: | 10.1111/j.1600-0714.2005.00340.x | SDG/關鍵字: | cell marker; HMB 45 cell marker; melan A; protein S 100; unclassified drug; adult; aged; article; clinical article; controlled study; diagnostic accuracy; female; human; immunochemistry; male; melanoma; nose cancer; nose mucosa; priority journal; Adult; Aged; Antigens, Neoplasm; Cell Nucleus; Coloring Agents; Cytoplasm; Female; Humans; Immunohistochemistry; Male; Melanocytes; Melanoma; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Nasal Mucosa; Neoplasm Proteins; Nose Neoplasms; S100 Proteins; Sensitivity and Specificity; Tumor Markers, Biological |
顯示於: | 臨床牙醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。