https://scholars.lib.ntu.edu.tw/handle/123456789/570381
標題: | Significantly higher frequencies of hematinic deficiencies and hyperhomocysteinemia in oral precancer patients | 作者: | Wu Y.-H. Wu Y.-C. Chu F.-Y. SHIH-JUNG CHENG Sun A. HSIN-MING CHEN |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 9 | 起(迄)頁: | 1299-1307 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Our previous studies found relatively higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia in patients with different types of oral mucosal diseases. This study evaluated whether patients with oral precancerous lesions (oral precancer patients) had significantly higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects. Methods: The complete blood count, serum iron, vitamin B12, folic acid, and homocysteine levels in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects were measured and compared. Results: We found significantly lower mean serum iron (for women only), vitamin B12, and folic acid levels and a significantly higher mean serum homocysteine level in oral precancer patients than in healthy control subjects (all P-values < 0.05). Moreover, 131 oral precancer patients had significantly higher frequencies of blood hemoglobin (3.1%), vitamin B12 (43.5%), and folic acid (46.6%) deficiencies and hyperhomocysteinemia (22.1%) than 131 healthy control subjects (all P-values < 0.05). Of 131 oral precancer patients, lower mean serum folic acid levels were found in 87 cigarette smokers than in 44 non-smokers (P = 0.002), in 26 smokers consuming > 20 cigarettes per day than in 61 smokers consuming ? 20 cigarettes per day (P = 0.024), and in 52 betel quid chewers than in 79 non-chewers (P = 0.051). Conclusion: There are significantly higher frequencies of anemia, serum vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in oral precancer patients than in healthy control subjects. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067126013&doi=10.1016%2fj.jfma.2019.05.016&partnerID=40&md5=6326c48410301b2cf25e7b4ddf81fc94 https://scholars.lib.ntu.edu.tw/handle/123456789/570381 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2019.05.016 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; antianemic agent; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; adult; aged; anemia; Article; betel quid; blood cell count; cigarette smoking; controlled study; drinking behavior; female; folic acid blood level; folic acid deficiency; hemoglobin blood level; human; hyperhomocysteinemia; hyperplasia; iron blood level; leukoplakia; major clinical study; male; mean corpuscular volume; mouth; precancer; smoking; anemia; B12 deficiency; blood; case control study; hyperhomocysteinemia; immunology; middle aged; mouth disease; pathology; sex factor; stomach parietal cell; Taiwan; Adult; Aged; Anemia; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Leukoplakia, Oral; Male; Middle Aged; Mouth Diseases; Parietal Cells, Gastric; Sex Factors; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency |
顯示於: | 牙醫學系 |
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