https://scholars.lib.ntu.edu.tw/handle/123456789/570441
標題: | Decreased expression of Ep-CAM protein is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan | 作者: | Hwang E.Y.-C. Yu C.-H. SHIH-JUNG CHENG JULIA YU-FONG CHANG HSIN-MING CHEN CHUN-PIN CHIANG |
公開日期: | 2009 | 卷: | 38 | 期: | 1 | 起(迄)頁: | 87-93 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Background: The epithelial cell adhesion molecule (Ep-CAM) is involved in cell signaling, migration, proliferation, cell-cycle regulation, and cancer metastasis. Methods: This study used an immunohistochemical technique to examine the expression of Ep-CAM protein in 84 specimens of oral squamous cell carcinoma (OSCC), 98 specimens of oral epithelial dysplasia (OED, 31 mild, 41 moderate, and 26 severe OED cases), and 15 specimens of normal oral mucosa (NOM). Results: We found that the mean Ep-CAM labeling indices (LIs) decreased significantly from NOM (80 ± 18%) and mild OED (76 ± 14%) through moderate OED (66 ± 22%) and severe OED (55 ± 20%) to OSCC samples (46 ± 16%, P < 0.001). A significant correlation was found between the lower mean Ep-CAM LI and OSCCs with larger tumor size (P = 0.003), positive lymph node metastasis (P = 0.022), more advanced clinical stages (P < 0.001), cancer recurrence (P = 0.021), or extracapsular spread of lymph node (P = 0.015). However, only Ep-CAM LI < 50% (P < 0.0001) was identified as an independent unfavorable prognosis factor by multivariate analyses with Cox proportional hazard regression model. Kaplan-Meier curve showed that OSCC patients with an Ep-CAM LI < 50% had a significantly poorer cumulative survival than those with an Ep-CAM LI ? 50% (P < 0.00001, log-rank test). Conclusions: We conclude that the decreased expression of Ep-CAM protein is an early event in oral carcinogenesis. The Ep-CAM LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients. ? 2008 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149161847&doi=10.1111%2fj.1600-0714.2008.00664.x&partnerID=40&md5=2cda4ecf4f4239e835ba443b991ba057 https://scholars.lib.ntu.edu.tw/handle/123456789/570441 |
ISSN: | 0904-2512 | DOI: | 10.1111/j.1600-0714.2008.00664.x | SDG/關鍵字: | epithelial cell adhesion molecule; adult; aged; article; cancer growth; cancer recurrence; controlled study; disease severity; dysplasia; female; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; male; mouth carcinoma; mouth mucosa; oral epithelial dysplasia; priority journal; prognosis; protein expression; squamous cell carcinoma; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carcinoma in Situ; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Disease Progression; Epithelium; Female; Forecasting; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Taiwan; Tumor Markers, Biological; Young Adult |
顯示於: | 牙醫學系 |
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