https://scholars.lib.ntu.edu.tw/handle/123456789/570885
標題: | Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: Molecular mechanisms and clinical significance | 作者: | HUNG-CHIH YANG JIA-HORNG KAO |
公開日期: | 2014 | 出版社: | Nature Publishing Group | 卷: | 3 | 期: | 9 | 來源出版物: | Emerging Microbes and Infections | 摘要: | Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection. cccDNA can persist in patients recovering from acute HBV infection for decades. This explains why HBV reactivation occasionally occurs in patients with resolved hepatitis B receiving intensive immunosuppressive agents. In addition, although advances in antiviral treatment dramatically improve the adverse outcomes of chronic hepatitis B (CHB), accumulating evidence demonstrates that current antiviral treatments alone, be they nucleos(t)ide analogs (NAs) or interferon (IFN), fail to cure most CHB patients because of the persistent cccDNA. NA suppresses HBV replication by directly inhibiting viral polymerase, while IFN enhances host immunity against HBV infection. Viral rebound often occurs after discontinuation of antiviral treatment. The loss of cccDNA can be induced by non-cytolytic destruction of cccDNA or immune-mediated killing of infected hepatocytes. It is known that NA has no direct effect on viral transcription or cccDNA stability. Therefore, the long half-life of hepatocytes leads to a very slow decline in cccDNA in patients under antiviral therapy. Novel antiviral agents targeting cccDNA or cccDNA-containing hepatocytes are thus required for curing chronic HBV infection. ? 2014 SSCC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919449705&doi=10.1038%2femi.2014.64&partnerID=40&md5=410842cc4bb9f40d126817320e9f9e7a https://scholars.lib.ntu.edu.tw/handle/123456789/570885 |
ISSN: | 2222-1751 | DOI: | 10.1038/emi.2014.64 | SDG/關鍵字: | antivirus agent; circular DNA; covalently closed circular DNA; relaxed circular DNA; unclassified drug; antiviral therapy; disease eradication; epigenetics; hepatitis B; Hepatitis B virus; history; human; life cycle; liver cell; microbial kinetics; nonhuman; persistent virus infection; priority journal; Review; virus transcription; Hepatitis B virus |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。