https://scholars.lib.ntu.edu.tw/handle/123456789/570922
標題: | Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C | 作者: | CHUN-JEN LIU YUNG-MING JENG PEI-JER CHEN Lai M.-Y HUNG-CHIH YANG Huang W.-L JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2005 | 出版社: | International Medical Press Ltd | 卷: | 10 | 期: | 3 | 起(迄)頁: | 405-415 | 來源出版物: | Antiviral Therapy | 摘要: | Background/aims: The prevalence and clinical implications of non-alcoholic fatty liver disease in patients with chronic hepatitis C remain unknown in Taiwan. Methods: We addressed the relevant issues by analysing 95 naive Taiwanese patients infected with either hepatitis C virus (HCV) genotype 1 (n=57) or 2 (n=38), receiving interferon alone (n=41) or in combination with ribavirin (n=54) therapy. A single pathologist scored steatosis and steatohepatitis at baseline and 24 weeks after antiviral treatment. Results: At baseline, steatosis and steatohepatitis were present in 44 (46%) and four (4%) patients, respectively. Variables associated with steatosis in logistical regression were hyperglycaemia (P=0.01), hypertriglyceridaemia (P=004) and body mass index >27 (P=0.009), but not HCV genotype or viral load. The grade of steatosis correlated well with the number of metabolic syndrome parameters (P=0.018). Interferon monotherapy, advanced age and HCV genotype 1, but not steatosis, correlated with lower sustained response rate. After treatment, steatosis improved in 19 and worsened in nine, which also did not correlate with HCV genotype (P=0.850) or sustained response to antiviral therapy (P=0.246). Conclusions: Hepatic steatosis in Taiwanese patients with chronic hepatitis C was associated with features of the metabolic syndrome, but did not correlate with HCV genotype, advanced fibrosis or the response to antiviral therapy. ? 2005 International Medical Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-20444457929&partnerID=40&md5=4d4940635d1a0e5abfd4094d14f2a9ab https://scholars.lib.ntu.edu.tw/handle/123456789/570922 |
ISSN: | 1359-6535 | SDG/關鍵字: | recombinant alpha2a interferon; recombinant alpha2b interferon; ribavirin; antivirus agent; adult; aging; article; body mass; correlation analysis; disease association; drug response; female; genotype; hepatitis C; human; human tissue; hyperglycemia; hypertriglyceridemia; liver fibrosis; major clinical study; male; metabolic syndrome X; monotherapy; nonalcoholic fatty liver; nonhuman; priority journal; steatohepatitis; steatosis; Taiwan; virus load; virus typing; disease course; fatty liver; genetics; genotype; hepatitis C; Hepatitis C virus; metabolic syndrome X; middle aged; pathophysiology; prevalence; Taiwan; Adult; Antiviral Agents; Disease Progression; Fatty Liver; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Metabolic Syndrome X; Middle Aged; Prevalence; Taiwan |
顯示於: | 醫學系 |
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