https://scholars.lib.ntu.edu.tw/handle/123456789/571449
標題: | Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats | 作者: | Chi T.-C. SHOEI-SHENG LEE MING-JAI SU |
公開日期: | 2006 | 卷: | 72 | 期: | 13 | 起(迄)頁: | 1175-1180 | 來源出版物: | Planta Medica | 摘要: | The antihyperglycemic actions of some aporphines and their derivatives in normal Wistar, streptozotocin (STZ)-induced diabetic (IDDM) and nicotinamide-STZ induced diabetic (NIDDM) rats were investigated in this study. These compounds included thaliporphine, glaucine, boldine, N-methyllaurotetanine, and predicentrine and the derivatives, N-[2-(2-methoxyphenoxy)ethyl]-norglaucine and diacetyl-N-allylsecoboldine. Bolus intravenous injection of these compounds decreased the plasma glucose levels in a dose-dependent manner in both normal and diabetic rats. Among them, thaliporphine was found to have the most potent antihyperglycemic effect in both NIDDM and IDDM diabetic rats. It was found that thaliporphine could stimulate the release of insulin in both normal and diabetic rats, and a dose of 1 mg per kg thaliporphine could significantly attenuate the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Similar treatment with thaliporphine significantly increased the skeletal muscle glycogen synthesis in both normal and diabetic rats. Hence, the hypoglycemic effect of thaliporphine in diabetic rats could be attributed to the stimulation of insulin release and the increase of glucose utilization. ? Georg Thieme Verlag KG Stuttgart. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751061976&doi=10.1055%2fs-2006-947199&partnerID=40&md5=03a0dcaa148ebae1862153f7f391175e https://scholars.lib.ntu.edu.tw/handle/123456789/571449 |
ISSN: | 320943 | DOI: | 10.1055/s-2006-947199 | SDG/關鍵字: | antidiabetic agent; aporphine derivative; boldine; diacetyl n allylsecoboldine; glaucine; glucose; insulin; n [2 (2 methoxyphenoxy)ethyl]norglaucine; n methyllaurotetanine; nicotinamide; predicentrine; streptozocin; thaliporphine; unclassified drug; animal experiment; animal model; article; controlled study; drug activity; drug structure; experimental rat; glucose blood level; glucose tolerance test; glycogen synthesis; insulin release; male; nonhuman; rat; streptozocin diabetes; Animals; Aporphines; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Male; Niacinamide; Plant Extracts; Rats; Rats, Wistar |
顯示於: | 藥學系 |
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