https://scholars.lib.ntu.edu.tw/handle/123456789/571504| Title: | Preparation and cytotoxic effect of ceanothic acid derivatives | Authors: | SHOEI-SHENG LEE Chen W.-C. CHIH-FEN HUANG Su Y. |
Issue Date: | 1998 | Journal Volume: | 61 | Journal Issue: | 11 | Start page/Pages: | 1343-1347 | Source: | Journal of Natural Products | Abstract: | Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031763893&doi=10.1021%2fnp9800856&partnerID=40&md5=aee165fd2925a3e93b8c08ae53792641 https://scholars.lib.ntu.edu.tw/handle/123456789/571504 |
ISSN: | 1633864 | DOI: | 10.1021/np9800856 | SDG/Keyword: | 1 decarboxy 3 oxoceanothic acid; 1 norceanothane derivative; betulic acid; ceanothane; ceanothic acid derivative; unclassified drug; article; cancer cell culture; drug cytotoxicity; drug isolation; drug structure; hela cell; structure activity relation; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Norsteroids; Plants, Medicinal; Spectrophotometry, Infrared; Triterpenes; Tumor Cells, Cultured [SDGs]SDG3 |
| Appears in Collections: | 藥學系 |
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