https://scholars.lib.ntu.edu.tw/handle/123456789/571504
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHOEI-SHENG LEE | en_US |
dc.contributor.author | Chen W.-C. | en_US |
dc.contributor.author | CHIH-FEN HUANG | en_US |
dc.contributor.author | Su Y. | en_US |
dc.date.accessioned | 2021-07-16T06:18:33Z | - |
dc.date.available | 2021-07-16T06:18:33Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1633864 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031763893&doi=10.1021%2fnp9800856&partnerID=40&md5=aee165fd2925a3e93b8c08ae53792641 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/571504 | - |
dc.description.abstract | Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5. | - |
dc.relation.ispartof | Journal of Natural Products | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 1 decarboxy 3 oxoceanothic acid; 1 norceanothane derivative; betulic acid; ceanothane; ceanothic acid derivative; unclassified drug; article; cancer cell culture; drug cytotoxicity; drug isolation; drug structure; hela cell; structure activity relation; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Norsteroids; Plants, Medicinal; Spectrophotometry, Infrared; Triterpenes; Tumor Cells, Cultured | - |
dc.title | Preparation and cytotoxic effect of ceanothic acid derivatives | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/np9800856 | - |
dc.identifier.pmid | 9834149 | - |
dc.identifier.scopus | 2-s2.0-0031763893 | - |
dc.relation.pages | 1343-1347 | - |
dc.relation.journalvolume | 61 | - |
dc.relation.journalissue | 11 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Pharmacy-NTUH | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.orcid | 0000-0002-6628-2448 | - |
crisitem.author.orcid | 0000-0003-1311-8828 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 藥學系 |
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