https://scholars.lib.ntu.edu.tw/handle/123456789/572018
標題: | Anti-neutrophil cytoplasmic antibody-associated pauci-immune crescentic glomerulonephritis complicating Sjögren's syndrome | 作者: | Wang W.-J. Wu H.-S. TZONG-SHINN CHU |
公開日期: | 七月-2011 | 出版社: | Elsevier B.V. | 卷: | 110 | 期: | 7 | 起(迄)頁: | 473-477 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Sj?gren's syndrome is a chronic autoimmune disease, characterized by specific autoimmune antibodies anti-Ro and anti-La, and it can involve multiple organs, such as the kidneys, lungs, muscles, and nervous system. The most common renal complication of Sj?gren's syndrome is tubulointerstitial nephritis, and glomerulonephritis is relatively uncommon. We report the case of an 86-year-old man presenting with recurrent fever, poor appetite, decreased salivary secretion, and body weight loss. Laboratory investigation revealed that serum creatinine was 4.2 mg/dL, proteinuria was 3+, and there was microscopic hematuria. Positive perinuclear anti-neutrophil cytoplasmic antibody, anti-Ro, and anti-La antibodies were detected. Renal biopsy showed crescentic glomerulonephritis with scanty immune complex deposition. The patient was diagnosed with primary Sj?gren's syndrome complicated with rapidly progressive glomerulonephritis with positive anti-neutrophil cytoplasmic antibody. Unlike the patients of other case reports, our patient's renal function did not recover after immunosuppressant treatment, and he finally received long-term hemodialysis. Pauci-immune glomerulonephritis is a rare renal complication of Sj?gren's syndrome, and progress to renal failure in such patients is possible. ? 2011 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960762373&doi=10.1016%2fS0929-6646%2811%2960070-3&partnerID=40&md5=5834b2eeea094b0b288e31f141d4e25a https://scholars.lib.ntu.edu.tw/handle/123456789/572018 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(11)60070-3 | SDG/關鍵字: | creatinine; cyclophosphamide; immunosuppressive agent; La antibody; methylprednisolone; neutrophil cytoplasmic antibody; prednisolone; Ro antibody; aged; antigen antibody complex; article; case report; cerebrovascular accident; creatinine blood level; decreased appetite; disease severity; hematuria; hemiplegia; hemodialysis; human; immunosuppressive treatment; kidney biopsy; kidney fibrosis; kidney function; laboratory test; male; microscopic hematuria; nephrolithiasis; physical examination; plasmapheresis; proteinuria; rapidly progressive glomerulonephritis; recurrent fever; renography; salivary gland disease; sepsis; Sjoegren syndrome; treatment outcome; urinalysis; weight reduction |
顯示於: | 醫學教育暨生醫倫理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。