https://scholars.lib.ntu.edu.tw/handle/123456789/572895
標題: | Coleus forskohlii and Garcinia indica extracts attenuated lipid accumulation by regulating energy metabolism and modulating gut microbiota in obese mice | 作者: | Tung Y.-C Shih Y.-A Nagabhushanam K Ho C.-T Cheng A.-C MIN-HSIUNG PAN |
關鍵字: | Mammals; Metabolism; Nutrition; Proteins; Adipose tissue; Beta oxidation; Energy imbalances; Energy metabolism; Garcinia indica; Gut microbiota; Lipid accumulations; Protein expressions; Fatty acids; lipid; plant extract; animal; Bacteroides; energy metabolism; Garcinia; intestine flora; mouse; mouse mutant; Plectranthus; Animals; Bacteroides; Energy Metabolism; Garcinia; Gastrointestinal Microbiome; Lipids; Mice; Mice, Obese; Plant Extracts; Plectranthus | 公開日期: | 2021 | 卷: | 142 | 來源出版物: | Food Research International | 摘要: | Obesity is related to energy imbalance and energy metabolism. In this study, we investigated the anti-obesity effects of Garcinia indica extract (GIE), Coleus forskohlii extract (CFE), and the combinations of these two extracts in a 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. In vitro, GIE showed better effect on TG content than CFE, CFE showed better effect on glycerol released than GIE, and the combinations of GIE and CFE showed both effects compared with GIE and CFE alone. In vivo, GIE, LMIX (0.005% GIE + 0.025% CFE), and HMIX (0.01% GIE + 0.025% CFE) down-regulated adipogenesis-related transcription factors PPARγ and C/EBPα protein expression, CFE promoted lipolysis by up-regulated p-HSL and p-PKA protein expression, and four supplementations promoted fatty acid β-oxidation by up-regulating CPT-1A and PPARα protein expression to decrease lipid accumulation in adipose tissue. Moreover, we found that CFE, LMIX and HMIX, except GIE exert increasing the abundance of Bacteroides caccae compared with HFD group. Overall, GIE, CFE, and the combinations of GIE and CFE were able to decrease body weight and adipocyte size by promoting fatty acid β-oxidation and modulating gut microbiota in HFD-induced obese mice. ? 2021 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100515629&doi=10.1016%2fj.foodres.2021.110143&partnerID=40&md5=29484b45ab1636f956b8af57818c2785 https://scholars.lib.ntu.edu.tw/handle/123456789/572895 |
ISSN: | 9639969 | DOI: | 10.1016/j.foodres.2021.110143 | SDG/關鍵字: | Mammals; Metabolism; Nutrition; Proteins; Adipose tissue; Beta oxidation; Energy imbalances; Energy metabolism; Garcinia indica; Gut microbiota; Lipid accumulations; Protein expressions; Fatty acids; lipid; plant extract; animal; Bacteroides; energy metab |
顯示於: | 食品科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。