https://scholars.lib.ntu.edu.tw/handle/123456789/572898
標題: | 3′-Hydroxydaidzein Improves Obesity through the Induced Browning of Beige Adipose and Modulation of Gut Microbiota in Mice with Obesity Induced by a High-Fat Diet | 作者: | Tung Y.-C Chou R.-F Nagabhushanam K Ho C.-T MIN-HSIUNG PAN |
關鍵字: | Flavonoids; Mammals; Metabolites; Tissue; Adipose tissue; Fermented soybeans; Gut microbiota; Lipid accumulations; Protein expressions; Total cholesterols; Triacylglycerols; White adipose tissues; Nutrition; 3'-hydroxydaidzein; isoflavone derivative; peroxisome proliferator activated receptor gamma coactivator 1alpha; Ppargc1a protein, mouse; sirtuin 1; uncoupling protein 1; adverse event; animal; beige adipose tissue; C57BL mouse; drug effect; energy metabolism; genetics; human; intestine flora; lipid diet; male; metabolism; microbiology; mouse; obesity; Adipose Tissue, Beige; Animals; Diet, High-Fat; Energy Metabolism; Gastrointestinal Microbiome; Humans; Isoflavones; Male; Mice; Mice, Inbred C57BL; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1; Uncoupling Protein 1 | 公開日期: | 2020 | 卷: | 68 | 期: | 49 | 起(迄)頁: | 14513-14522 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Obesity is an important health issue nowadays. 3′-Hydroxydaidzein (OHD) is a metabolite of daidzein (DAI) that can be found in fermented soybean products, such as miso. DAI has been known to affect lipid accumulation, but the effect of OHD on lipid accumulation still needs to be investigated. In this study, we investigated the effects of OHD on mice with obesity induced by a high-fat diet (HFD). The results showed that mice treated with 0.1% OHD (HOHD) significantly reduced their body weight and inguinal fat without altering their food intake compared with the HFD group. The HOHD and DAI groups' hyperlipidemia were alleviated through decreased serum triacylglycerols and total cholesterol levels. The adipocyte sizes in inguinal fat were significantly smaller in the HOHD and DAI groups compared with the HFD group. Both the HOHD and DAI groups had increased PRDM16, C/EBP β, p-p38, SIRT1, PGC1 α, and UCP1 protein expression in their inguinal adipose tissue compared with the HFD group. Moreover, the OHD and DAI groups had significantly lower amounts of Lachnospira and GCA_900066225 compared with the HFD group. Collectively, OHD can ameliorate HFD-induced obesity in mice by stimulating the browning of the white adipose tissue and modulating gut microbiota. ? 2020 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097585584&doi=10.1021%2facs.jafc.0c06138&partnerID=40&md5=25b4b35dba5aa4d0e36d0f9dba1a07a6 https://scholars.lib.ntu.edu.tw/handle/123456789/572898 |
ISSN: | 218561 | DOI: | 10.1021/acs.jafc.0c06138 | SDG/關鍵字: | Flavonoids; Mammals; Metabolites; Tissue; Adipose tissue; Fermented soybeans; Gut microbiota; Lipid accumulations; Protein expressions; Total cholesterols; Triacylglycerols; White adipose tissues; Nutrition; 3'-hydroxydaidzein; isoflavone derivative; peroxisome proliferator activated receptor gamma coactivator 1alpha; Ppargc1a protein, mouse; sirtuin 1; uncoupling protein 1; adverse event; animal; beige adipose tissue; C57BL mouse; drug effect; energy metabolism; genetics; human; intestine flora; lipid diet; male; metabolism; microbiology; mouse; obesity; Adipose Tissue, Beige; Animals; Diet, High-Fat; Energy Metabolism; Gastrointestinal Microbiome; Humans; Isoflavones; Male; Mice; Mice, Inbred C57BL; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1; Uncoupling Protein 1 |
顯示於: | 食品科技研究所 |
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