https://scholars.lib.ntu.edu.tw/handle/123456789/572918
標題: | Randomized Controlled Trial of One Anastomosis Gastric Bypass Versus Roux-En-Y Gastric Bypass for Obesity: Comparison of the YOMEGA and Taiwan Studies | 作者: | Lee W.-J Almalki O.M Ser K.-H JEN-CHIH CHEN Lee Y.-C. |
關鍵字: | hemoglobin A1c; abdominal pain; adult; anus fistula; bile reflux; body mass; body weight loss; comparative study; controlled study; diarrhea; female; follow up; gastric bypass surgery; Gastrointestinal Quality of Life Index; glycemic control; hemoglobin blood level; high risk patient; human; intestine anastomosis; intestine obstruction; jejunum ulcer; major clinical study; malabsorption; male; malnutrition; metabolic syndrome X; obesity; one anastomosis gastric bypass; operation duration; patient safety; peroperative complication; postoperative complication; postoperative pain; priority journal; quality of life; randomized controlled trial; reoperation; Review; Roux-en-Y gastric bypass; surgical patient; Taiwan; abdominal pain; adverse event; anastomosis; bile reflux; gastric bypass surgery; glucose blood level; malabsorption; metabolism; middle aged; morbid obesity; multicenter study (topic); pathology; physiology; postoperative complication; procedures; randomized controlled trial (topic); stomach; Abdominal Pain; Adult; Anastomosis, Surgical; Bile Reflux; Blood Glucose; Body Mass Index; Female; Gastric Bypass; Humans; Malabsorption Syndromes; Male; Middle Aged; Multicenter Studies as Topic; Obesity, Morbid; Operative Time; Postoperative Complications; Randomized Controlled Trials as Topic; Stomach; Taiwan; Weight Loss | 公開日期: | 2019 | 卷: | 29 | 期: | 9 | 起(迄)頁: | 3047-3053 | 來源出版物: | Obesity Surgery | 摘要: | Background: The YOMEGA study (Y-study) was a randomized trial comparing one anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB). Here, we aim to compare the Y-study and our pioneer trial from Taiwan (T-study). Methods: Data from the Y-study and the T-study were collected and compared. Results: The Y-study recruited 234 patients with a mean body mass index (BMI) of 43.9 and age of 43.5?years. The T-study recruited 80 patients with a similar mean BMI of 44.3 and mean age of 31.4?years. The studies had similar findings including (1) OAGB is easier and possibly safer procedure than RYGB. Both studies showed that OAGB had a shorter operation time than RYGB, but a lower surgical complication rate was only demonstrated in T-study. (2) Both procedures have similar weight loss but OAGB features better glycemic control than RYGB. Weight loss at 2?years after surgery was similar between two procedures, but OAGB reduced HbA1c to a greater degree than RYGB at 2?years in Y-study (? 2.3% vs. ? 1.3%; p = 0.025). The resolution of the metabolic syndrome was 100% for both groups in the T-study. (3) OAGB carried a higher risk of malnutrition. OAGB had more malabsorptive problems with a lower hemoglobin level than RYGB at 2?years after surgery. Adverse malnutrition events occurred in nine (7.8%) OAGB patients in the Y-study. Four (3.4%) patients of OAGB received revision surgery in Y-study but none in T-study. (4) Bile reflux was noted in OAGB patients but did not influence quality of life or revision rate. Y-study found that bile in the gastric pouch was present in 16% of patients in the OAGB group versus none in the RYGB, but no inter-group difference in quality of life was detected. There was a trend for RYGB patients to experience more abdominal pain than OAGB. Conclusions: Both studies showed that OAGB is a technically easier procedure and features better glycemic control than RYGB, but has a mal-absorptive effect. However, the bile reflux and abdominal pain controversies persisted. ? 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068841514&doi=10.1007%2fs11695-019-04065-2&partnerID=40&md5=3e9689c90b823794e8c9af93ef8d1ef0 https://scholars.lib.ntu.edu.tw/handle/123456789/572918 |
ISSN: | 9608923 | DOI: | 10.1007/s11695-019-04065-2 |
顯示於: | 生物科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。