https://scholars.lib.ntu.edu.tw/handle/123456789/572928
標題: | HSCRP as surrogate marker in predicting long term effect of bariatric surgery on resolution of non-alcoholic steatohepatitis | 作者: | Tan C.-H Al-Kalifah N Lee W.-J Ser K.-H Lee Y.-C JEN-CHIH CHEN |
關鍵字: | biological marker; C reactive protein; adult; bariatric surgery; blood; body weight loss; complication; female; follow up; human; liver cell carcinoma; liver tumor; male; morbid obesity; nonalcoholic fatty liver; predictive value; prevalence; time factor; treatment outcome; young adult; Adult; Bariatric Surgery; Biomarkers; C-Reactive Protein; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Non-alcoholic Fatty Liver Disease; Obesity, Morbid; Predictive Value of Tests; Prevalence; Time Factors; Treatment Outcome; Weight Loss; Young Adult | 公開日期: | 2019 | 卷: | 42 | 期: | 1 | 起(迄)頁: | 203-208 | 來源出版物: | Asian Journal of Surgery | 摘要: | Background: Nonalcoholic steatohepatitis (NASH) is closely associated with obesity and is one of the important etiologies of hepatocellular carcinoma (HCC and liver failure. Bariatric surgery is proven to be effective in causing weight loss and improvement of NASH) but there is limited long term data. Objectives: To identify the predictors of NASH in morbidly obese patients and evaluate long term data of bariatric surgery effects on NASH. Methods: 308 bariatric patients (mean age 30.2 years old, body mass index (BMI) 45.0 kg/m 2 ) with concurrent liver biopsy form 2003 to 2008 were included. We compared the clinical data between the NASH and non-NASH group and identify predictors of NASH in this cohort of patients. Remission of NASH was evaluated using the predictor of NASH. Results: Prevalence of NASH was 43.8%. At baseline, the NASH and non-NASH groups both had similar age, BMI and sex ratio but the NASH group had significantly worse glycemic control, liver enzymes, triglycerides and uric acid. Highly sensitive-C Reactive Protein (HSCRP) level was identified as the only independent predictor of NASH. Ten years follow up (60.4% loss to follow up) showed good weight loss, resolution of co-morbidities and reduction of HSCRP. Patients with bypass surgery had better weight loss and lower levels of HSCRP. (HSCRP 0.2 ± 0.1 mg/dL vs. 0.8 ± 0.7 mg/dL, p = 0.009). than non-bypass group. Conclusion: NASH is common in bariatric patients. HSCRP is the only independent predictor of NASH and can be used as a surrogate marker in predicting long term effect of Bariatric Surgery on resolution of non-alcoholic steatohepatitis Bypass procedure was better in resolution of NASH than non-bypass procedure. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047271278&doi=10.1016%2fj.asjsur.2018.04.010&partnerID=40&md5=6f2996ddaa7ebfbd4dd043bb9b646c73 https://scholars.lib.ntu.edu.tw/handle/123456789/572928 |
ISSN: | 10159584 | DOI: | 10.1016/j.asjsur.2018.04.010 |
顯示於: | 生物科技研究所 |
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