https://scholars.lib.ntu.edu.tw/handle/123456789/573002
標題: | Toxicokinetic/toxicodynamic-based risk assessment of freshwater fish health posed by microplastics at environmentally relevant concentrations | 作者: | Chen C.-Y Lu T.-H Yang Y.-F CHUNG-MIN LIAO |
關鍵字: | Detoxification; Fish; Health; Health risks; Microplastic; Pollution; Water; Benchmark concentrations; Concentration-dependent manners; Continental scale; Environmental concentration; Freshwater ecosystem; Freshwater fishes; Mean residence time; Risk assessment framework; Risk assessment; fresh water; plastic; animal; Asia; ecosystem; human; risk assessment; toxicity; toxicokinetics; water pollutant; Animals; Asia; Ecosystem; Fresh Water; Humans; Microplastics; Plastics; Risk Assessment; Toxicokinetics; Water Pollutants, Chemical | 公開日期: | 2020 | 來源出版物: | Science of the Total Environment | 摘要: | The pervasive contamination of microplastics (MPs) in freshwater ecosystems is of emerging concern. Mechanistic link between exposure and effect on assessing health risk of freshwater fish posed by environmental MPs, however, is more limited. Our study filled this gap by developing a toxicokinetic/toxicodynamic (TK/TD)-based risk assessment framework to examine health effects of zebrafish and red tilapia responses to environmental concentrations of MPs appraised with a variety of valuable published data on a global scale. We assessed organ-specific TK parameters and mean residence times for polystyrene (PS)-MPs-exposed freshwater fish in size- and concentration-dependent manners. We estimated the relatively sensitive benchmark concentrations (BMCs) of PS-MPs for oxidative stress in zebrafish and detoxification in red tilapia to be ~1.0 and ~119 μg g?1, respectively. Based on continental scale MPs trends, the high MPs concentrations were over Asia, with a mean value of 36 mg L?1. Given metabolic disturbances in zebrafish and red tilapia as bioindicators, we found that MPs pollution was highly likely to enhance fish health risks and that this factor must therefore be considered in evaluations of MPs susceptibility of freshwater fish. Our TK/TD-based risk scheme could help inform intensified efforts to mitigate environmental MPs pollution in order to benefit freshwater fish species and people who depend on healthy stocks of different fish. ? 2020 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097038895&doi=10.1016%2fj.scitotenv.2020.144013&partnerID=40&md5=2595312e6567cafb07e15c92aca7d7f7 https://scholars.lib.ntu.edu.tw/handle/123456789/573002 |
ISSN: | 489697 | DOI: | 10.1016/j.scitotenv.2020.144013 | SDG/關鍵字: | Detoxification; Fish; Health; Health risks; Microplastic; Pollution; Water; Benchmark concentrations; Concentration-dependent manners; Continental scale; Environmental concentration; Freshwater ecosystem; Freshwater fishes; Mean residence time; Risk assessment framework; Risk assessment; fresh water; plastic; animal; Asia; ecosystem; human; risk assessment; toxicity; toxicokinetics; water pollutant; Animals; Asia; Ecosystem; Fresh Water; Humans; Microplastics; Plastics; Risk Assessment; Toxicokinetics; Water Pollutants, Chemical |
顯示於: | 生物環境系統工程學系 |
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