https://scholars.lib.ntu.edu.tw/handle/123456789/575515
標題: | Clinical application of sirolimus in renal transplantation: An update | 作者: | SHIH-CHIEH CHUEH Kahan B.D. |
公開日期: | 2005 | 卷: | 18 | 期: | 3 | 起(迄)頁: | 261-277 | 來源出版物: | Transplant International | 摘要: | In addition to an analysis of the final results of phase I/II and phase III clinical trials of sirolimus (SRL), this review focuses on the recent results of several studies in renal transplantation, which include diverse combinations of SRL with other immunosuppressive agents. While SRL was initially introduced as an adjunctive agent to calcineurin inhibitors, it is now serving as the base for therapies that spare or avoid these nephrotoxic drugs. However, to optimize the use of SRL as base therapy, further work is necessary to determine target concentrations, requirement for concomitant steroids and/or nucleoside synthesis blockers, and countermeasure therapy to overcome the drug's adverse effects. ? 2005 European Society for Organ Transplantation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-20844456618&doi=10.1111%2fj.1432-2277.2004.00039.x&partnerID=40&md5=789fd1aea91e46a0fa203742555f5f66 https://scholars.lib.ntu.edu.tw/handle/123456789/575515 |
ISSN: | 0934-0874 | DOI: | 10.1111/j.1432-2277.2004.00039.x | SDG/關鍵字: | aciclovir; azathioprine; basiliximab; calcineurin inhibitor; cyclosporin; cytochrome P450; glycoprotein P; immunoglobulin; immunosuppressive agent; mycophenolic acid 2 morpholinoethyl ester; placebo; rapamycin; steroid; tacrolimus; cyclosporin; immunosuppressive agent; rapamycin; tacrolimus; anemia; artery thrombosis; bacterial infection; bronchiolitis obliterans; cellulitis; clinical trial; cytokine release; cytomegalovirus infection; diarrhea; drug dose reduction; edema; gastrointestinal disease; graft failure; graft rejection; hematologic disease; hernia; herpes simplex; herpes zoster; human; hypercholesterolemia; hyperlipidemia; hypertension; hypertriglyceridemia; hyperuricemia; hypokalemia; hypomagnesemia; kidney polycystic disease; kidney transplantation; leukopenia; liver dysfunction; liver toxicity; lymphocele; motor neuropathy; mycosis; nephrotoxicity; neurogenic bladder; pneumonia; priority journal; review; side effect; thrombocytopenia; urinary tract infection; drug combination; graft rejection; liver transplantation; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Transplantation; Sirolimus; Tacrolimus |
顯示於: | 醫學系 |
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