https://scholars.lib.ntu.edu.tw/handle/123456789/575665
標題: | NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients | 作者: | CHING-CHU LU RUOH-FANG YEN Peng, Kang-Yung JEI-YIE HUANG KWAN-DUN WU SHIH-CHIEH CHUEH WAN-YU LIN |
關鍵字: | KCNJ5; NP-59 adrenal scintigraphy; mutation prediction; primary aldosteronism; semiquantification | 公開日期: | 2021 | 卷: | 12 | 來源出版物: | Frontiers in endocrinology | 摘要: | Somatic KCNJ5 mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is a noninvasive functional study for disease activity assessment. This study aimed to evaluate the predictive value of NP-59 adrenal scintigraphy in somatic KCNJ5 mutation among PA patients who received adrenalectomy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/575665 | ISSN: | 1664-2392 | DOI: | 10.3389/fendo.2021.644927 | SDG/關鍵字: | dexamethasone; macrolide; adrenal scintiscanning; adrenalectomy; adult; Article; computer assisted tomography; dexamethasone suppression test; diagnostic test accuracy study; disease activity; DNA sequencing; female; gene mutation; human; kcnj5 gene; major clinical study; male; phenotype; primary hyperaldosteronism; retrospective study; sensitivity and specificity; single photon emission computed tomography |
顯示於: | 醫學系 |
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