https://scholars.lib.ntu.edu.tw/handle/123456789/575761
標題: | Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation | 作者: | Jian H.-J HUAN-TSUNG CHANG et al. |
關鍵字: | Adhesives; Biocompatibility; Biofilms; Carbon; Carbon Quantum Dots; Contact lenses; Escherichia coli; Nanocrystals; Neurophysiology; Physiological models; Salmonella; Semiconductor quantum dots; Anti-bacterial activity; Anti-biofilm; Anti-microbial activity; Bacterial keratitis; Dopamine; Gram-positive bacterium; Minimal inhibitory concentration; Polyamines; Amines | 公開日期: | 2020 | 卷: | 386 | 來源出版物: | Chemical Engineering Journal | 摘要: | We demonstrate the synthesis of antibacterial carbon quantum dots (CQDs) through a one-step pyrolysis of biogenic polyamine (PA) and dopamine (DA) mixture. SPM/DA-CQDs synthesized from DA combined with spermine (SPM) exhibit effective antibacterial activity and high adhesion properties on glass and surfaces of polymeric contact lens material. The antimicrobial activity of SPM/DA-CQDs is primarily due to their ability to disrupt the bacterial membrane, and they possess wide spectrum antimicrobial activity against Gram-negative bacteria (Escherichia coli, Salmonella enterica serovar Enteritidis, and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and its multidrug-resistant strain, methicillin-resistant S. aureus). The minimal inhibitory concentration (MIC) of SPM/DA-CQDs against the tested bacteria was >17-fold and >7-fold lower than those of CQDs prepared solely from spermine and dopamine, respectively. The great biocompatibility of our SPM/DA-CQDs is revealed from the in vitro cytotoxicity and hemolysis assays and in vivo evaluation of morphological and physiological changes of rabbit corneas. We further prepared SPM/DA-CQDs-coated coverslips and contact lenses, which display excellent stability and antibiofilm properties. Moreover, in vivo tests show that SPM/DA-CQDs suppress bacterial keratitis (BK) formation in a corneal-injured rabbit model. Our results indicate that SPM/DA-CQDs have great potential as a coating material for inhibition of biofilm formation on contact lenses, and broadly to protect medical devices from contamination. ? 2019 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078562260&doi=10.1016%2fj.cej.2019.123913&partnerID=40&md5=f9707a97e1fb477e8454066459f89942 https://scholars.lib.ntu.edu.tw/handle/123456789/575761 |
ISSN: | 13858947 | DOI: | 10.1016/j.cej.2019.123913 |
顯示於: | 化學系 |
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