https://scholars.lib.ntu.edu.tw/handle/123456789/575840
標題: | Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy | 作者: | Chan M.-H Hsieh M.-R Liu R.-S Wei D.-H Hsiao M. RU-SHI LIU |
關鍵字: | Cells; Chemotherapy; Controlled drug delivery; Diseases; Iron; Iron oxides; Kaolinite; Magnetic fluids; Magnetite; Nanocomposites; Nanomagnetics; Nanoparticles; Scaffolds (biology); Targeted drug delivery; Cetyltrimethylammonium bromide; Chemotherapeutic drugs; Drug delivery system; Hepatocellular carcinoma; Long-term retention; Magnetic fluid hyperthermia; Systematic analysis; Therapeutic treatments; Magnetic resonance imaging | 公開日期: | 2020 | 卷: | 32 | 期: | 2 | 起(迄)頁: | 697-708 | 來源出版物: | Chemistry of Materials | 摘要: | Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T1-weighted or T2-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe3O4 or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form FePt@Kao nanocomposites. Multifunctional FePt@Kao can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, FePt@Kao-Dox can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized FePt@Kao-Dox nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system. Copyright ? 2019 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078672700&doi=10.1021%2facs.chemmater.9b03552&partnerID=40&md5=e9d410ef643ecd79bba67f1011760723 https://scholars.lib.ntu.edu.tw/handle/123456789/575840 |
ISSN: | 8974756 | DOI: | 10.1021/acs.chemmater.9b03552 | SDG/關鍵字: | Cells; Chemotherapy; Controlled drug delivery; Diseases; Iron; Iron oxides; Kaolinite; Magnetic fluids; Magnetite; Nanocomposites; Nanomagnetics; Nanoparticles; Scaffolds (biology); Targeted drug delivery; Cetyltrimethylammonium bromide; Chemotherapeutic drugs; Drug delivery system; Hepatocellular carcinoma; Long-term retention; Magnetic fluid hyperthermia; Systematic analysis; Therapeutic treatments; Magnetic resonance imaging |
顯示於: | 化學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。