https://scholars.lib.ntu.edu.tw/handle/123456789/576784
標題: | Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials | 作者: | Yeh S.-L Wang T.-C Yusa S.-I Thissen H Tsai W.-B. WEI-BOR TSAI |
公開日期: | 2021 | 卷: | 6 | 期: | 5 | 起(迄)頁: | 3517-3524 | 來源出版物: | ACS Omega | 摘要: | Antifouling treatment is critical to certain biomedical devices for their functions and patients' life. Facial, versatile, and universal coating methods to conjugate antifouling materials on a wide variety of biomaterials are beneficial for the fabrication of low-fouling biomedical devices. We developed a simple one-step coating method for surface conjugation of zwitterionic poly(sulfobetaine) via deposition of self-polymerized pyrogallol (PG). Poly(pyrogallol) could deposit copolymers of sulfobetaine methacrylate and aminoethyl methacrylate (pSBAE) on various biomaterials. pSBAE coatings inhibited as high as 99.8% of the adhesion of L929 cells and reduced protein adsorption significantly. The resistance against L929 cell adhesion was increased with increasing coating time and was positively correlated with the surface hydrophilicity and film thickness. Such a coating was robust to resist harsh sterilization conditions and stable for long-term storage in phosphate-buffered saline. We expect that the simple low-fouling pSBAE coating is applicable to the manufacture of medical devices. ? 2021 The Authors. Published by American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102569613&doi=10.1021%2facsomega.0c04643&partnerID=40&md5=b802f40c5157d95f80dab93ce0c34a93 https://scholars.lib.ntu.edu.tw/handle/123456789/576784 |
ISSN: | 24701343 | DOI: | 10.1021/acsomega.0c04643 |
顯示於: | 化學工程學系 |
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