https://scholars.lib.ntu.edu.tw/handle/123456789/577088
標題: | Stimulation and recording of cardiac contractions by using a cardiac-and-piezoelectric hybrid system | 作者: | Yang C.-F Huang Y.-H Hsu Y.-H. YU-HSIANG HSU |
關鍵字: | Electromagnetic pulse; Hybrid systems; Piezoelectricity; Tissue culture; Cardiac contraction; Cardiac tissues; Cardiomyocytes; Electrical stimulations; Hybrid platform; Isoproterenol; Piezoelectric; Piezoelectric sensors; Heart | 公開日期: | 2018 | 卷: | 2 | 起(迄)頁: | 808-810 | 來源出版物: | 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 | 摘要: | In this paper, we report a cardiac-and-piezoelectric hybrid system that uses a flexible piezoelectric sensor to measure the contraction profile of cardiac tissue cultured on its surface. This system is based on a cardiac-and-piezoelectric hybrid platform that we developed and reported previously. In this study, we integrate an electrical stimulating system to facilitate the maturation of cultured cardiomyocyte. Furthermore, a faraday cage was designed to minimize the electromagnetic interference for enhancing signal output. Finally, we verify the performance of this system by using a commercial drug: Isoproterenol, and the screening result showed similar range of EC50 value. Copyright ? (2018) by Chemical and Biological Microsystems Society. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077894287&partnerID=40&md5=006bd2ddeb397421905e6d21167cb4db https://scholars.lib.ntu.edu.tw/handle/123456789/577088 |
顯示於: | 應用力學研究所 |
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