https://scholars.lib.ntu.edu.tw/handle/123456789/577139
Title: | Curcumin-loaded hydrophobic surface-modified hydroxyapatite as an antioxidant for sarcopenia prevention | Authors: | Liang Y.-J Yang I.-H Lin Y.-W Lin J.-N Wu C.-C Chiang C.-Y Lai K.-H Lin F.-H. Lin, Feng-Huei |
Issue Date: | 2021 | Journal Volume: | 10 | Journal Issue: | 4 | Source: | Antioxidants | Abstract: | Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly ad-ministered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-in-flammatory and anti-oxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, uti-lized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxi-dant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydro-phobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104491114&doi=10.3390%2fantiox10040616&partnerID=40&md5=a0a978cd32676ead815e261ba680c0e6 https://scholars.lib.ntu.edu.tw/handle/123456789/577139 |
ISSN: | 20763921 | DOI: | 10.3390/antiox10040616 |
Appears in Collections: | 醫學工程學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.