https://scholars.lib.ntu.edu.tw/handle/123456789/577243
標題: | The synergistic effect of hyperthermia and chemotherapy in magnetite nanomedicine-based lung cancer treatment | 作者: | Yang, Shu-Jyuan Huang, Chung-Huan Wang, Chung-Hao MING-JIUM SHIEH KE-CHENG CHEN |
關鍵字: | cisplatin; human serum albumin; magnetite nanoparticle; methotrexate; polystyrenesulfonate sodium; superparamagnetic iron oxide nanoparticle; cisplatin; drug carrier; magnetite; methotrexate; methotrexate-serum albumin; nanoparticle; serum albumin; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; biocompatibility; cancer chemotherapy; controlled study; drug delivery system; drug stability; drug targeting; female; high temperature procedures; human; human cell; in vitro study; in vivo study; lung cancer; monotherapy; mouse; nonhuman; radiation exposure; synergistic effect; thermotherapy; tumor localization; animal; chemistry; lung tumor; multimodality cancer therapy; nanomedicine; procedures; tumor cell line; Animals; Cell Line, Tumor; Cisplatin; Combined Modality Therapy; Drug Carriers; Ferrosoferric Oxide; Humans; Hyperthermia, Induced; Lung Neoplasms; Methotrexate; Nanomedicine; Nanoparticles; Serum Albumin | 公開日期: | 2020 | 卷: | 15 | 起(迄)頁: | 10331-10347 | 來源出版物: | International Journal of Nanomedicine | 摘要: | Background: Lung cancer is the leading cause of cancer patient death in the world. There are many treatment options for lung cancer, including surgery, radiation therapy, chemother-apy, targeted therapy, and combined therapy. Despite significant progress has been made in the diagnosis and treatment of lung cancer during the past few decades, the prognosis is still unsatisfactory. Purpose: To resolve the problem of chemotherapy failure, we developed a magnetite-based nanomedicine for chemotherapy acting synergistically with loco-regional hyperthermia. Methods: The targeting carrier consisted of a complex of superparamagnetic iron oxide (SPIO) and poly(sodium styrene sulfonate) (PSS) at the core and a layer-by-layer shell with cisplatin (CDDP), together with methotrexate – human serum albumin conjugate (MTX ?HSA conjugate) for lung cancer-specific targeting, referred to hereafter as SPIO@PSS/ CDDP/HSA?MTX nanoparticles (NPs). Results: SPIO@PSS/CDDP/HSA?MTX NPs had good biocompatibility and stability in physiological solutions. Furthermore, SPIO@PSS/CDDP/HSA?MTX NPs exhibited a higher temperature increase rate than SPIO nanoparticles under irradiation by a radiofrequency (RF) generator. Therefore, SPIO@PSS/CDDP/HSA?MTX NPs could be used as a hyperthermia inducer under RF exposure after nanoparticles preferentially targeted and then accumulated at tumor sites. In addition, SPIO@PSS/CDDP/HSA?MTX NPs were developed to be used during combined chemotherapy and hyperthermia therapy, exhibiting a synergistic anticancer effect better than the effect of monotherapy. Conclusion: Both in vitro and in vivo results suggest that the designed SPIO@PSS/CDDP/ HSA?MTX NPs are a powerful candidate nanoplatform for future antitumor treatment strategies. ? 2020 Yang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098855730&doi=10.2147%2fIJN.S281029&partnerID=40&md5=8819dcfb0f59ce6ab6ce032f547fff01 https://scholars.lib.ntu.edu.tw/handle/123456789/577243 |
ISSN: | 11769114 | DOI: | 10.2147/IJN.S281029 | SDG/關鍵字: | cisplatin; human serum albumin; magnetite nanoparticle; methotrexate; polystyrenesulfonate sodium; superparamagnetic iron oxide nanoparticle; cisplatin; drug carrier; magnetite; methotrexate; methotrexate-serum albumin; nanoparticle; serum albumin; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; biocompatibility; cancer chemotherapy; controlled study; drug delivery system; drug stability; drug targeting; female; high temperature procedures; human; human cell; in vitro study; in vivo study; lung cancer; monotherapy; mouse; nonhuman; radiation exposure; synergistic effect; thermotherapy; tumor localization; animal; chemistry; lung tumor; multimodality cancer therapy; nanomedicine; procedures; tumor cell line; Animals; Cell Line, Tumor; Cisplatin; Combined Modality Therapy; Drug Carriers; Ferrosoferric Oxide; Humans; Hyperthermia, Induced; Lung Neoplasms; Methotrexate; Nanomedicine; Nanoparticles; Serum Albumin |
顯示於: | 醫學系 |
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