https://scholars.lib.ntu.edu.tw/handle/123456789/577244
標題: | Residence Time-Extended Nanoparticles by Magnetic Field Improve the Eradication Efficiency of Helicobacter pylori | 作者: | Yang S.-J. Huang C.-H. JYH-CHIN YANG Wang C.-H. Shieh M.-J. MING-JIUM SHIEH |
關鍵字: | Antibiotics; Biocompatibility; Chitosan; Diseases; Drug dosage; Hydrochloric acid; Iron oxides; Magnetic fields; Magnetic nanoparticles; Bactericidal effects; Biofilm inhibitions; Gastric cancers; Helicobacter pylori; Helicobacter pylori infections; Mucoadhesive properties; Superparamagnetic iron oxide nanoparticles; Treatment failure; Drug delivery; acrylic acid resin; amoxicillin; antiinfective agent; biomaterial; chitosan; chitosan-poly(acrylic acid); drug carrier; ferric ion; ferric oxide; magnetite nanoparticle; animal; Bagg albino mouse; biofilm; cell line; chemistry; drug effect; Helicobacter infection; Helicobacter pylori; human; isolation and purification; magnetic field; metabolism; microbiology; mouse; pathology; physiology; stomach mucosa; time factor; veterinary medicine; Acrylic Resins; Amoxicillin; Animals; Anti-Bacterial Agents; Biocompatible Materials; Biofilms; Cell Line; Chitosan; Drug Carriers; Ferric Compounds; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Magnetic Fields; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Time Factors | 公開日期: | 2020 | 卷: | 12 | 期: | 49 | 起(迄)頁: | 54316-54327 | 來源出版物: | ACS Applied Materials and Interfaces | 摘要: | Helicobacter pylori infection is one of the leading causes of several gastroduodenal diseases, such as gastritis, peptic ulcer, and gastric cancer. In fact, H. pylori eradication provides a preventive effect against the incidence of gastric cancer. Amoxicillin is a commonly used antibiotic for H. pylori eradication. However, due to its easy degradation by gastric acid, it is necessary to administer it in a large dosage and to combine it with other antibiotics. This complexity and the strong side effects of H. pylori eradication therapy often lead to treatment failure. In this study, the chitosan/poly (acrylic acid) particles co-loaded with superparamagnetic iron oxide nanoparticles and amoxicillin (SPIO/AMO@PAA/CHI) are used as drug nano-carriers for H. pylori eradication therapy. In vitro and in vivo results show that the designed SPIO/AMO@PAA/CHI nanoparticles are biocompatible and could retain the biofilm inhibition and the bactericidal effect of amoxicillin against H. pylori. Moreover, the mucoadhesive property of chitosan allows SPIO/AMO@PAA/CHI nanoparticles to adhere to the gastric mucus layer and rapidly pass through the mucus layer after exposure to a magnetic field. When PAA is added, it competes with amoxicillin for chitosan, so that amoxicillin is quickly and continuously released between the mucus layer and the gastric epithelium and directly acts on H. pylori. Consequently, the use of this nano-carrier can extend the drug residence time in the stomach, reducing the drug dose and treatment period of H. pylori eradication therapy. ? |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097825784&doi=10.1021%2facsami.0c13101&partnerID=40&md5=a79cb50b67ba116cfdec84d3b42d1264 https://scholars.lib.ntu.edu.tw/handle/123456789/577244 |
ISSN: | 19448244 | DOI: | 10.1021/acsami.0c13101 | SDG/關鍵字: | Antibiotics; Biocompatibility; Chitosan; Diseases; Drug dosage; Hydrochloric acid; Iron oxides; Magnetic fields; Magnetic nanoparticles; Bactericidal effects; Biofilm inhibitions; Gastric cancers; Helicobacter pylori; Helicobacter pylori infections; Mucoadhesive properties; Superparamagnetic iron oxide nanoparticles; Treatment failure; Drug delivery; acrylic acid resin; amoxicillin; antiinfective agent; biomaterial; chitosan; chitosan-poly(acrylic acid); drug carrier; ferric ion; ferric oxide; magnetite nanoparticle; animal; Bagg albino mouse; biofilm; cell line; chemistry; drug effect; Helicobacter infection; Helicobacter pylori; human; isolation and purification; magnetic field; metabolism; microbiology; mouse; pathology; physiology; stomach mucosa; time factor; veterinary medicine; Acrylic Resins; Amoxicillin; Animals; Anti-Bacterial Agents; Biocompatible Materials; Biofilms; Cell Line; Chitosan; Drug Carriers; Ferric Compounds; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Magnetic Fields; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Time Factors |
顯示於: | 醫學系 |
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