https://scholars.lib.ntu.edu.tw/handle/123456789/577653
標題: | Mercury, APOE, and children's neurodevelopment | 作者: | Ng S. CHINGCHUN LIN YAW-HUEI HWANG Hsieh W.-S. Liao H.-F. PAU-CHUNG CHEN |
公開日期: | 2013 | 出版社: | Elsevier B.V. | 卷: | 37 | 起(迄)頁: | 85-92 | 來源出版物: | NeuroToxicology | 摘要: | The benefit of the nutritious elements in fish is insufficient for explaining the controversial finding regarding prenatal mercury (Hg) exposure and neurodevelopment; the varying frequency of susceptible genes among these populations may shed light on these observations. However, limited studies have been reported on the association between genetic susceptibility of prenatal Hg exposure and child development. Apolipoprotein E (APOE, protein; Apoe, gene) is a major protein transporter expressed in the brain. The Apoe epsilon 4 (ε4) allele is associated with poor neural repair function and is a risk factor associated with Alzheimer disease. We conducted a prospective cohort study in 2004 and 2005. In this study, 168 subjects were recruited at delivery and followed up at two years of age, and genetic polymorphisms of Apoe were included to assess genetic susceptibility and to determine the relationship between Hg concentrations in cord blood and neurodevelopment. The results showed that adverse effects on neurodevelopment were consistently associated with prenatal Hg exposure in all subtests of Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) among ε4 carriers as assessed by both simple linear and multiple linear regression models. After controlling for confounding factors, statistical significance was found in the subtests of cognition tests (β=. -8.47, 95% confidence interval (CI). =. -16.10 to -0.84), social tests (β=. -11.02, 95% CI. =. -20.85 to -1.19) and the whole test of CDIIT (β=. -10.45, 95% CI. =. -17.36 to -3.54) in a multiple linear regression model. Additionally, the interaction effect between gene polymorphisms of Apoe and Hg levels was significant in the whole test CDIIT and subtests of cognition, language and fine motor tests. In conclusion, Apoe modifies the adverse effects of cord blood Hg on neurodevelopment at the age of two years. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877807722&doi=10.1016%2fj.neuro.2013.03.012&partnerID=40&md5=c915eabd8d2483c70d1fdad2fcc2723a https://scholars.lib.ntu.edu.tw/handle/123456789/577653 |
ISSN: | 0161-813X | DOI: | 10.1016/j.neuro.2013.03.012 | SDG/關鍵字: | apolipoprotein E; mercury; adult; APOE epsilon 4 gene; Apoe gene; article; blood level; child; child development; cognition; cohort analysis; Comprehensive Developmental Inventory for Infants and Toddlers; controlled study; delivery; female; follow up; genetic polymorphism; genetic susceptibility; heterozygote; human; language test; male; motor activity; named inventories, questionnaires and rating scales; nerve cell differentiation; neurologic examination; neurotoxicity; prenatal exposure; preschool child; priority journal; prospective study; umbilical cord blood |
顯示於: | 環境與職業健康科學研究所 |
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