https://scholars.lib.ntu.edu.tw/handle/123456789/578018
標題: | Antimicrobial susceptibility of bacteremic vancomycin-resistant Enterococcus faecium to eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics: Results from the 2019–2020 Nationwide Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) | 作者: | Tsai, Hsih-Yeh Lee, Yu-Lin Liu, Po-Yu Lu, Min-Chi PEI-LAN SHAO Lu, Po-Liang Cheng, Shu-Hsing Ko, Wen-Chien Lin, Chi-Ying Wu, Ting-Shu Yen, Muh-Yong Wang, Lih-Shinn Liu, Chang-Pan Lee, Wen-Sen Shi, Zhi-Yuan Chen, Yao-Shen Wang, Fu-Der Tseng, Shu-Hui Chen, Yu-Hui WANG-HUEI SHENG Lee, Chun-Ming Chen, Yen-Hsu Liao, Chun-Hsing PO-REN HSUEH |
關鍵字: | Eravacycline; Lipoglycopeptides; Omadacycline; Tedizolid; Vancomycin-resistant Enterococcus faecium | 公開日期: | 七月-2021 | 卷: | 58 | 期: | 1 | 來源出版物: | International journal of antimicrobial agents | 摘要: | Multicenter surveillance of antimicrobial susceptibility was performed for 235 vancomycin-resistant Enterococcus faecium (VREfm) isolates from 18 Taiwanese hospitals. The minimum inhibitory concentrations (MICs) of eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics were determined using the broth microdilution method. Nearly all isolates of VREfm were not susceptible to teicoplanin, dalbavancin, and telavancin, with susceptibility rates of 0.5%, 1.7% and 0.5%, respectively. Tigecycline and eravacycline were active against 93.2% and 89.7% of the VREfm isolates, respectively. Moreover, the susceptibility rates of quinupristin/dalfopristin, tedizolid, and linezolid were 59.1%, 84.2%, and 77.4%, respectively. Additionally, 94% of the VREfm isolates were classified as susceptible to daptomycin, and the MICs of omadacycline required to inhibit VREfm growth by 50% and 90% were 0.12 and 0.5 mg/L, respectively. Susceptibility rates of VREfm isolates to synthetic tetracyclines and daptomycin were slightly lower and to oxazolidinone-class antibiotics were much lower in Taiwan than those in other parts of the world. Continuous monitoring of VREfm resistance to novel antibiotics, including synthetic tetracyclines, oxazolidinone-class antibiotics, and daptomycin, is needed in Taiwan. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/578018 | ISSN: | 09248579 | DOI: | 10.1016/j.ijantimicag.2021.106353 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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