https://scholars.lib.ntu.edu.tw/handle/123456789/578027
標題: | Scrub typhus and antibiotic-resistant Orientia tsutsugamushi | 作者: | Lu, Chin-Te Wang, Lih-Shinn PO-REN HSUEH |
關鍵字: | Orientia tsutsugamushi; antibiotic-resistant; rickettsial infection; scrub typhus; tsutsugamushi triangle | 公開日期: | 21-六月-2021 | 來源出版物: | Expert review of anti-infective therapy | 摘要: | Introduction: Scrub typhus is one of the most underdiagnosed and under-reported febrile illnesses requiring hospitalization, mainly occurring in Southeast and East Asia and the Pacific Islands, in an area referred to as the 'Tsutsugamushi Triangle.' Scrub typhus is a zoonotic rickettsial disease that is transmitted to humans by trombiculid mites.Areas covered: A MEDLINE/PubMed search of the available literature was performed to describe the role of antibiotic-resistant scrub typhus in therapy failure.Expert opinion: Scrub typhus is characterized by an eschar that may appear 2-3 days before sudden-onset fever with chills, headache, backache, myalgia, profuse sweating, vomiting, and enlarged lymph nodes. A macular or maculopapular skin rash can develop within 3-8 days after the onset of fever. Various antibiotics, such as chloramphenicol, tetracycline, doxycycline, macrolides, quinolones, and rifampicin, have been used to treat scrub typhus. Resistance to tetracycline has been proposed to underlie delayed clinical improvement since 1996, but recent reports have questioned the existence of doxycycline resistance. Nevertheless, the existence and importance of antibiotic-resistant scrub typhus remain uncertain and require further study. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/578027 | ISSN: | 14787210 | DOI: | 10.1080/14787210.2021.1941869 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。