https://scholars.lib.ntu.edu.tw/handle/123456789/578405
標題: | Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population-based case-control study | 作者: | Lin C.-H. Hung P.-H. Hu H.-Y. Chung C.-J. Chen T.-H. KUAN-YU HUNG |
關鍵字: | children; claims data; systemic lupus erythematosus; urticaria | 公開日期: | 2018 | 出版社: | Blackwell Publishing Ltd | 卷: | 29 | 期: | 7 | 起(迄)頁: | 732-739 | 來源出版物: | Pediatric Allergy and Immunology | 摘要: | Background: Urticaria is one of the most common diseases seen in clinical practice, whereas several reports have proposed that urticaria may have a link with autoimmune disorders. Few studies have examined the clinical association between urticaria with systemic lupus erythematosus (SLE). By conducting a nationwide population-based case-control study in Taiwan, we evaluated the risk of SLE in children with a prior clinical diagnosis of urticaria. Methods: Using 2000-2011 claims data from the Taiwanese National Health Insurance Research Database, we identified 2105 SLE children during 2004-2011 as the study group, along with randomly selected 8420 non-SLE patients matched (1:4) for age, sex, and first diagnosis date as the control group. The correlation between urticaria and SLE risk was estimated using conditional logistic regression analysis. Results: The prevalence rates of clinically diagnosed acute and chronic urticaria in SLE patients were 22.09% and 18.24%, respectively. A significant association was found between clinically diagnosed urticaria and childhood SLE, with a stronger risk associated with more episodes of urticaria (?3 visits, OR: 2.33, 95% CI 1.91-2.84). The risk was higher with chronic urticaria (OR: 2.21, 95% CI 1.85-2.64) than with acute urticaria (OR: 1.54, 95% CI 1.34-1.76). Subgroup analysis stratified by sex or age indicated that the risk associated with SLE was significantly greater among female children and adolescents with urticaria. Conclusions: Our results suggest that children with urticaria have a significantly higher risk of SLE, with the risk increasing further among those with more episodes of urticaria or chronic urticaria. ? 2018 The Authors. Pediatric Allergy and Immunology Published by John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052813955&doi=10.1111%2fpai.12962&partnerID=40&md5=807d06fdf6ba1848693d38847c99c970 https://scholars.lib.ntu.edu.tw/handle/123456789/578405 |
ISSN: | 0905-6157 | DOI: | 10.1111/pai.12962 | SDG/關鍵字: | adolescent; allergic rhinitis; Article; association; atopic dermatitis; autoinflammatory disease; child; childhood disease; chronic urticaria; clinical practice; controlled study; female; human; infection; infection caused urticaria; major clinical study; male; onset age; population based case control study; preschool child; prevalence; priority journal; risk factor; school child; sex difference; systemic lupus erythematosus; Taiwan; urticaria; case control study; complication; factual database; systemic lupus erythematosus; urticaria; Adolescent; Case-Control Studies; Child; Child, Preschool; Databases, Factual; Female; Humans; Lupus Erythematosus, Systemic; Male; Prevalence; Risk Factors; Taiwan; Urticaria |
顯示於: | 醫學系 |
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