https://scholars.lib.ntu.edu.tw/handle/123456789/578415
標題: | Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: A nationwide population-based study | 作者: | Lin C.-H. Hung P.-H. Hu H.-Y. Chen Y.-J. Guo H.-R. KUAN-YU HUNG |
關鍵字: | end-stage renal disease; hospitalization; infection; National Health Insurance; systemic lupus erythematosus | 公開日期: | 2017 | 出版社: | Oxford University Press | 卷: | 32 | 期: | 10 | 起(迄)頁: | 1683-1690 | 來源出版物: | Nephrology Dialysis Transplantation | 摘要: | Background Infections are a major cause of morbidity in patients with systemic lupus erythematosus (SLE), and may lead to death. No nationally representative study of patients with SLE has examined the rates of infection-related hospitalization and the risk of end-stage renal disease (ESRD). Methods We conducted a nationwide cohort study of 7326 patients with newly diagnosed SLE and no history of ESRD. All data were from Taiwan's National Health Insurance claims database for the period 2000-11. Results Among all SLE patients, 316 (4.3%) developed ESRD (mean follow-up time: 8.1 years). Multivariate Cox regression analysis indicated that the risk of ESRD increased with the number of infection-related hospitalizations. For patients with three or more infection-related admissions, the hazard ratio (HR) for ESRD was 5.08 [95% confidence interval (CI): 3.74-6.90] relative to those with no infection-related admission. Analysis by type of infection indicated that bacteremia patients had the greatest risk for ESRD (HR: 4.82; 95% CI: 3.40-6.85). Analysis of age of SLE onset indicated that patients with juvenile-onset (<18 years) and three or more infection-related hospitalizations had a greatly increased risk for ESRD (HR: 14.49; 95% CI: 5.34-39.33). Conclusions Infection-related hospitalizations are associated with a significantly increased risk of ESRD in patients with SLE, especially those with juvenile-onset SLE. Among patients with different types of infectious diseases, those with bacteremia were more likely to develop ESRD. ? The Authors 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030699136&doi=10.1093%2fndt%2fgfw407&partnerID=40&md5=09fe091bd4a8c8bf030d03e3359620e7 https://scholars.lib.ntu.edu.tw/handle/123456789/578415 |
ISSN: | 0931-0509 | DOI: | 10.1093/ndt/gfw407 | SDG/關鍵字: | azathioprine; calcineurin inhibitor; cyclophosphamide; hydroxychloroquine; methotrexate; mycophenolic acid; prednisolone; adult; Article; bacteremia; cellulitis; cohort analysis; controlled study; end stage renal disease; female; high risk patient; hospital admission; hospitalization; human; incidence; infection; major clinical study; male; onset age; pneumonia; population research; priority journal; risk factor; septicemia; sex difference; soft tissue infection; systemic lupus erythematosus; Taiwan; urinary tract infection; urogenital tract infection; adolescent; bacterial infection; chronic kidney failure; complication; hospitalization; middle aged; mortality; multivariate analysis; proportional hazards model; systemic lupus erythematosus; young adult; Adolescent; Adult; Age of Onset; Bacterial Infections; Cohort Studies; Female; Hospitalization; Humans; Incidence; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Risk Factors; Young Adult |
顯示於: | 醫學系 |
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