https://scholars.lib.ntu.edu.tw/handle/123456789/578762
標題: | Uremic toxins, oxidative stress, and renal fibrosis: An interwined complex | 作者: | CHIA-TER CHAO CHIH-KANG CHIANG |
公開日期: | 2015 | 出版社: | W.B. Saunders | 卷: | 25 | 期: | 2 | 起(迄)頁: | 155-159 | 來源出版物: | Journal of Renal Nutrition | 摘要: | The prevalence of end-stage renal diseases is currently on the rise globally, and finding the way to curb this tide is urgently needed. Tubulointerstitial fibrosis is a common pathway for essentially all the nephropathy categories known to date, and the manifestations of renal fibrosis include excessive deposition of extracellular matrix with distortion of renal microstructures and functional deterioration. Uremic toxins have been gradually found to play an important role in the development of progressive renal fibrosis, with protein-bound indoxyl sulfate, p-cresol, and p-cresyl sulfate receiving the most attention. However, the contribution of oxidative stress among the pathogenesis of uremic toxins and renal fibrosis has not been evaluated much until recently. In this review, we will discuss about the nature and sources of oxidative stress in the kidney and how uremic toxins use oxidative stress to orchestrate the processes of renal fibrosis. ? 2015 National Kidney Foundation, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925185825&doi=10.1053%2fj.jrn.2014.10.010&partnerID=40&md5=8b7a917912d696484707f4be4d48a443 https://scholars.lib.ntu.edu.tw/handle/123456789/578762 |
ISSN: | 1051-2276 | DOI: | 10.1053/j.jrn.2014.10.010 | SDG/關鍵字: | chronic kidney failure; complication; fibrosis; human; kidney; oxidative stress; pathophysiology; physiology; uremia; Fibrosis; Humans; Kidney; Kidney Failure, Chronic; Oxidative Stress; Uremia |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。