https://scholars.lib.ntu.edu.tw/handle/123456789/578863
標題: | The origin of Acinetobacter baumannii TYTH-1: A comparative genomics study | 作者: | Liu C.-C. Tang C.Y. HAN-YUEH KUO Lu C.-W. Chang K.-C. Liou M.-L. |
關鍵字: | Acinetobacter baumannii; Comparative genomics | 公開日期: | 2013 | 卷: | 41 | 期: | 4 | 起(迄)頁: | 318-324 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | There have been increasing reports of blaOXA-23-carrying strains of carbapenem-resistant Acinetobacter baumannii (CRAB), which has become a significant public health concern in Taiwan. To determine the origin of these CRAB strains, the prevalence of CRAB and blaOXA-23-carrying CRAB in a regional hospital was analysed retrospectively. The genome of A. baumannii TYTH-1 was completely sequenced and annotated. Multiple comparative genomics studies, including phylogenetic analysis, functional comparison via the Clusters of Orthologous Groups (COGs) database, and determination of variance in GC profiles in the whole genome and gene arrangements in resistance islands, were performed using 11 completely sequenced A. baumannii genomes. bla OXA-23-carrying CRAB isolates became dominant clones in 2007. A comparative genomics analysis revealed a common strain lineage between Taiwanese strains (TYTH-1 and TCDC-AB0715) and Chinese strains (MDR-TJ and MDR-ZJ06). Phylogenetic studies and GC profiles showed that the genome of TYTH-1 was closest to MDR-ZJ06. However, the resistance island of TYTH-1 (RI TYTH-1) was nearly identical to that of RIMDT-TJ. The functional category for COGs was similar in the tested genomes. The results reveal that dissemination of blaOXA-23-carrying CRAB in Taiwan may have been mediated by the transfer of people between Taiwan and China during 2007. The global spread of CRAB is now a worldwide public health problem. In Taiwan, the government needs to focus more attention on the importance of identifying and tracing resistant pathogens and issuing notifications of CRAB infections. ? 2013 Elsevier B.V. and the International Society of Chemotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875369533&doi=10.1016%2fj.ijantimicag.2012.12.010&partnerID=40&md5=22f67711a3f4ebd89cd53297c4cd03d4 https://scholars.lib.ntu.edu.tw/handle/123456789/578863 |
ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2012.12.010 | SDG/關鍵字: | amikacin; ampicillin; antibiotic agent; beta lactamase; beta lactamase OXA 23; cefazolin; ceftazidime; ceftriaxone; ciprofloxacin; gentamicin; imipenem; levofloxacin; piperacillin plus tazobactam; sulbactam; sultamicillin; tobramycin; unclassified drug; Acinetobacter baumannii; antibiotic resistance; article; bacterial genome; bacterial transmission; bacterium isolate; case report; China; clone; controlled study; gene sequence; human; minimum inhibitory concentration; multidrug resistance; nonhuman; nucleotide sequence; phylogeny; pneumonia; priority journal; retrospective study; sepsis; Taiwan; Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cross Infection; Disease Outbreaks; Drug Resistance, Multiple, Bacterial; Fatal Outcome; Genome, Bacterial; Genomics; Humans; Microbial Sensitivity Tests; Phylogeny; Retrospective Studies; Sequence Analysis, DNA; Taiwan |
顯示於: | 醫學系 |
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