https://scholars.lib.ntu.edu.tw/handle/123456789/579224
標題: | The role played by perivascular cells in kidney interstitial injury | 作者: | Rojas A. FAN-CHI CHANG SHUEI-LIONG LIN Duffield J.S. |
公開日期: | 2012 | 卷: | 77 | 期: | 5 | 起(迄)頁: | 400-408 | 來源出版物: | Clinical Nephrology | 摘要: | Fibrosis of the kidney is a disease affecting millions worldwide and is a harbinger of progressive loss of organ function resulting in organ failure. Recent findings suggest that understanding mechanisms of development and progression of fibrosis will lead to new therapies urgently required to counteract loss of organ function. Recently, little-known cells that line the kidney microvasculature, known as pericytes, were identified as the precursor cells which become the scar-forming myofibroblasts. Kidney pericytes are extensively branched cells located in the wall of capillaries, embedded within the microvascular basement membrane, and incompletely envelope endothelial cells with which they establish focal contacts. In response to kidney injuries, pericytes detach from endothelial cells and migrate into the interstitial space where they undergo a transition into myofibroblasts. Detachment leads to fibrosis but also leaves an unstable endothelium, prone to rarefaction. Endothelial-pericyte crosstalk at the vascular endothelial growth factor receptors and platelet derived growth factor receptors in response to injury have been identified as major new targets for therapeutic intervention. ? 2012 Dustri-Verlag Dr. K. Feistle. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861518893&doi=10.5414%2fCN107371&partnerID=40&md5=9f61cf0ee631e25dcaf73d9e85938e71 https://scholars.lib.ntu.edu.tw/handle/123456789/579224 |
ISSN: | 0301-0430 | DOI: | 10.5414/CN107371 | SDG/關鍵字: | 5' nucleotidase; alpha smooth muscle actin; CD45 antigen; platelet derived growth factor alpha receptor; platelet derived growth factor BB; platelet derived growth factor beta receptor; platelet derived growth factor receptor; vasculotropin receptor; angiogenesis; arteriole; article; capillary wall; cell function; cell interaction; cell migration; endothelium cell; fibroblast; human; kidney fibrosis; kidney injury; kidney interstitium; mesangium cell; microvasculature; myofibroblast; nonhuman; pericyte; podocyte; protein expression; smooth muscle fiber; vascular smooth muscle; venule; Animals; Capillaries; Cell Communication; Cell Transdifferentiation; Endothelial Cells; Fibrosis; Humans; Kidney; Kidney Diseases; Myofibroblasts; Neovascularization, Physiologic; Pericytes |
顯示於: | 醫學系 |
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