https://scholars.lib.ntu.edu.tw/handle/123456789/579386
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHI-TING SU | en_US |
dc.contributor.author | Urban Z. | en_US |
dc.date.accessioned | 2021-08-24T05:21:47Z | - |
dc.date.available | 2021-08-24T05:21:47Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107129282&doi=10.3390%2fgenes12060795&partnerID=40&md5=3e7ca22b91ace5a416de25ffa093cb08 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/579386 | - |
dc.description.abstract | Latent transforming growth factor β (TGFβ)-binding protein (LTBP) 4, a member of the LTBP family, shows structural homology with fibrillins. Both these protein types are characterized by calcium-binding epidermal growth factor-like repeats interspersed with 8-cysteine domains. Based on its domain composition and distribution, LTBP4 is thought to adopt an extended structure, facilitating the linear deposition of tropoelastin onto microfibrils. In humans, mutations in LTBP4 result in autosomal recessive cutis laxa type 1C, characterized by redundant skin, pulmonary emphysema, and valvular heart disease. LTBP4 is an essential regulator of TGFβ signaling and is related to development, immunity, injury repair, and diseases, playing a central role in regulating inflammation, fibrosis, and cancer progression. In this review, we focus on medical disorders or diseases that may be manipulated by LTBP4 in order to enhance the understanding of this protein. ? 2021 by the authors. Licensee. MDPI, Basel, Switzerland. | - |
dc.publisher | MDPI AG | - |
dc.relation.ispartof | Genes | - |
dc.subject | Elastogenesis; LTBP4; Medicine; TGFβ | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fibulin 5; latent transforming growth factor beta binding protein; latent transforming growth factor beta binding protein 1; latent transforming growth factor beta binding protein 2; latent transforming growth factor beta binding protein 3; latent transforming growth factor beta binding protein 4; mitogen activated protein kinase; Rho factor; Rho kinase; Smad1 protein; Smad5 protein; Smad6 protein; Smad7 protein; Smad8 protein; transforming growth factor beta; unclassified drug; latent transforming growth factor beta binding protein; LTBP4 protein, human; abdominal aortic aneurysm; actin filament; Article; cardiovascular disease; cutis laxa; Duchenne muscular dystrophy; enzyme activation; extracellular matrix; human; liver cell carcinoma; lung disease; non small cell lung cancer; nonhuman; protein function; protein localization; protein secretion; protein structure; scleroderma; signal transduction; tight junction; transcription regulation; animal; genetic predisposition; genetics; metabolism; pathology; Animals; Cutis Laxa; Genetic Predisposition to Disease; Humans; Latent TGF-beta Binding Proteins; Muscular Dystrophy, Duchenne | - |
dc.title | Ltbp4 in health and disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/genes12060795 | - |
dc.identifier.pmid | 34071145 | - |
dc.identifier.scopus | 2-s2.0-85107129282 | - |
dc.relation.pages | 795 | - |
dc.relation.journalvolume | 12 | - |
dc.relation.journalissue | 6 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.orcid | 0000-0002-2926-3950 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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