https://scholars.lib.ntu.edu.tw/handle/123456789/579858
標題: | Investigation of the Therapeutic Effect of Doxorubicin Combined With Focused Shockwave on Glioblastoma | 作者: | Liao, Wei-Hao MING-YEN HSIAO Kung, Yi ABEL PO-HAO HUANG WEN-SHIANG CHEN |
關鍵字: | BBB; blood-brain barrier; doxorubicin; glioblastoma multiforme; shockwave | 公開日期: | 2021 | 卷: | 11 | 來源出版物: | Frontiers in oncology | 摘要: | Glioblastoma multiforme (GBM) is currently the most devastating brain tumor globally and produces a high mortality rate. GBM is also challenging to eradicate using surgery due to its invasive characteristics. Moreover, the blood-brain barrier (BBB) increases the difficulty of transporting most therapeutic drugs to tumor sites. The use of transcranial focused ultrasound (FUS) has recently been investigated for opening the BBB to facilitate drug delivery. A special form of FUS, the shockwave (SW), has also been shown to open BBB efficiently. SW has several advantages including no heating effect, less reactive oxygen species production, good transcranial ability, and no need to supply microbubbles. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/579858 | ISSN: | 2234-943X | DOI: | 10.3389/fonc.2021.711088 |
顯示於: | 醫學系 |
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