https://scholars.lib.ntu.edu.tw/handle/123456789/580264
標題: | Asian consensus workshop report: Expert consensus guideline for the management of intermediate and advanced hepatocellular carcinoma in Asia | 作者: | Han K.-H. Kudo M. Ye S.-L. Choi J.Y. Poon R.T.-P. Seong J. Park J.-W. Ichida T. Chung J.W. Chow P. ANN-LII CHENG |
關鍵字: | Advanced stage; Diagnosis; Epidemiology; Hepatocellular carcinoma; Intermediate stage; Outcome; Staging system; Survival; Treatment | 公開日期: | 2011 | 卷: | 81 | 期: | SUPPL. 1 | 起(迄)頁: | 158-164 | 來源出版物: | Oncology | 摘要: | Hepatocellular carcinoma (HCC) is a highly prevalent disease in many Asian countries, accounting for 80% of victims worldwide. Screening programs improve the detection of early HCC and have a positive impact on survival, but the majority of HCC patients in Asia still present with advanced stage disease. The treatment outcomes of HCC are affected by multiple variables, including liver function, performance status of the patient, and tumor stage. Therefore, it is not easy to apply a multidisciplinary therapeutic approach for optimal management. At present, limited numbers of HCC patients are eligible for curative therapies such as surgery or ablation in Asia. Therefore, most patients are eligible for only palliative treatments. For optimal management, the treatment choice is guided by staging systems and treatment guidelines. Numerous staging systems have been proposed and treatment guidelines vary by region. According to the Barcelona Clinic Liver Cancer (BCLC) guideline based on evidence from randomized clinical trials, only transarterial chemoembolization (TACE) is recommended for intermediate stage HCC and sorafenib for advanced stage HCC. However, treatment guidelines from Asian countries have adopted several other therapeutic modalities such as a surgical approach, hepatic arterial infusion chemotherapy, external radiation, and their combinations based on clinical experiences for intermediate and advanced stage HCC. Although TACE is the main therapeutic modality in the intermediate stage, overall therapeutic outcomes depend on the tumor size. In the advanced stage, the prognosis depends on the tumor status, e.g. major vessel invasion or extrahepatic spread. Thus, a new staging system representing prognoses suitable for Asian HCC patients and a corresponding optimal treatment algorithm should be further investigated using evidence-based data, which will finally bring about an Asian consensus for the management of intermediate and advanced stage HCC. Copyright ? 2011 S. Karger AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855300819&doi=10.1159%2f000333280&partnerID=40&md5=864eaa0138f786446873a0a8dae9d4e0 https://scholars.lib.ntu.edu.tw/handle/123456789/580264 |
DOI: | 10.1159/000333280 | SDG/關鍵字: | sorafenib; advanced cancer; Asia; cancer chemotherapy; cancer staging; cancer surgery; cancer survival; clinical trial; conference paper; human; liver cell carcinoma; liver function; multimodality cancer therapy; practice guideline; priority journal; Asia; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Guidelines as Topic; Humans; Liver Neoplasms; Neoplasm Staging; Survival Rate; Treatment Outcome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。