https://scholars.lib.ntu.edu.tw/handle/123456789/581612
標題: | A 45-year experience of uveal melanoma in Taiwan: Verification of American Joint Committee on Cancer staging system and prognostic factors | 作者: | Ma S.-T. YI-TING HSIEH YI-HSUAN WEI SHU-LANG LIAO |
關鍵字: | Ciliary body; Melanoma; Neoplasm metastases; Uvea neoplasms | 公開日期: | 2021 | 出版社: | Elsevier B.V. | 卷: | 120 | 期: | 6 | 起(迄)頁: | 1361-1368 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: To verify the staging system of the American Joint Committee on Cancer (AJCC) 8th edition for uveal melanoma, and to propose the prognostic factors of uveal melanoma by a 45-year cohort study. Methods: We collected patients who underwent operation with pathological proof from 1973 to 2017. The demographic data including gender, age, laterality, metastatic pattern, and histopathology type were recorded. The predictability for survival and monotonicity of gradients of the AJCC 8th edition were evaluated. The prognostic factors for survival were analyzed by univariate and multivariate analysis. Results: A total of 72 patients were collected. The median age was 55 year-old (range 24–100). No specific gender predilection was revealed in our study. About 75.9% of metastases events happened in the first five-year of follow-up, and hepatic involvement was the most common. By the AJCC 8th edition, the distribution for stage I: II: III was 8 (11.1%), 37 (51.4%), and 27 (37.5%). The prognostic staging groups manifested fair predictability and monotonicity of gradients for survival outcome. The tumors with epithelioid cell type and ciliary body involvements had higher tumor-related mortality. Conclusion: The AJCC 8th edition prognostic staging groups for outcome prediction was validated. Periodic screening for metastases should be more frequent in the first five-year follow-up. The tumors with epithelioid cell pattern and ciliary body involvements were at risk of higher tumor-related mortality in Taiwanese patients. ? 2020 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094610405&doi=10.1016%2fj.jfma.2020.10.016&partnerID=40&md5=201c3df44a9d63f2771a766dc864e185 https://scholars.lib.ntu.edu.tw/handle/123456789/581612 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2020.10.016 | SDG/關鍵字: | antineoplastic agent; adult; aged; Article; cancer diagnosis; cancer immunotherapy; cancer prognosis; cancer radiotherapy; cancer staging; cancer survival; ciliary body; cohort analysis; controlled study; demography; distant metastasis; echography; epithelioid histiocyte; eye enucleation; female; follow up; histopathology; human; liver function test; major clinical study; male; medical examination; multivariate analysis; positron emission tomography; retrospective study; sex difference; survival time; Taiwan; tumor volume; univariate analysis; uvea melanoma; whole body MRI; cancer staging; epidemiology; melanoma; middle aged; neoplasm; prognosis; United States; uvea tumor; Cohort Studies; Humans; Melanoma; Middle Aged; Neoplasm Staging; Neoplasms; Prognosis; Retrospective Studies; Taiwan; United States; Uveal Neoplasms |
顯示於: | 醫學系 |
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