https://scholars.lib.ntu.edu.tw/handle/123456789/581728
標題: | Sustained virological response to hepatitis C therapy does not decrease the incidence of systemic lupus erythematosus or rheumatoid arthritis | 作者: | Hsu W.-F. Chen C.-Y. Tseng K.-C. Lai H.-C. Kuo H.-T. Hung C.-H. Tung S.-Y. Wang J.-H. Chen J.-J. Lee P.-L. Chien R.-N. Lin C.-Y. Yang C.-C. Lo G.-H. Tai C.-M. Lin C.-W. JIA-HORNG KAO CHUN-JEN LIU CHEN-HUA LIU Yan S.-L. Bair M.-J. Su W.-W. Chu C.-H. Chen C.-J. Lo C.-C. Cheng P.-N. Chiu Y.-C. Wang C.-C. Cheng J.-S. Tsai W.-L. Lin H.-C. Huang Y.-H. Tsai P.-C. Huang J.-F. Dai C.-Y. Chuang W.-L. Yu M.-L. Peng C.-Y. |
公開日期: | 2020 | 出版社: | Nature Research | 卷: | 10 | 期: | 1 | 起(迄)頁: | 5372 | 來源出版物: | Scientific Reports | 摘要: | In patients with chronic hepatitis C (CHC), the effects of baseline characteristics, virological profiles, and therapeutic outcome to pegylated interferon plus ribavirin (PR) therapy on autoimmune diseases are unknown. Taiwanese Chronic Hepatitis C Cohort is a nationwide hepatitis C virus registry cohort comprising 23 hospitals of Taiwan. A total of 12,770 CHC patients receiving PR therapy for at least 4 weeks between January 2003 and December 2015 were enrolled and their data were linked to the Taiwan National Health Insurance Research Database for studying the development of 10 autoimmune diseases. The mean follow-up duration was 5.3 ± 2.9 years with a total of 67,930 person-years, and the annual incidence of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) was 0.03%. Other autoimmune diseases were not assessable due to few events. Body mass index ?24 kg/m2 was an independent predictor of the low incidence of SLE or RA (hazard ratio 0.40, 95% confidence interval 0.17–0.93, p = 0.034). A sustained virological response (SVR) to PR therapy was not associated with the low incidence of SLE or RA in any subgroup analysis. CHC patients achieving SVR to PR therapy did not exhibit an impact on the incidence of SLE or RA compared with non-SVR patients. ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082470585&doi=10.1038%2fs41598-020-61991-3&partnerID=40&md5=3e9f63e9723d896bf69ff3ca13415faf https://scholars.lib.ntu.edu.tw/handle/123456789/581728 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-61991-3 | SDG/關鍵字: | alpha interferon; antivirus agent; macrogol; ribavirin; adult; autoimmune disease; chronic hepatitis C; cohort analysis; combination drug therapy; complication; drug effect; epidemiology; female; hepatitis C; human; incidence; male; middle aged; procedures; proportional hazards model; rheumatoid arthritis; sustained virologic response; systemic lupus erythematosus; Taiwan; virus load; Adult; Antiviral Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Cohort Studies; Drug Therapy, Combination; Female; Hepatitis C; Hepatitis C, Chronic; Humans; Incidence; Interferon-alpha; Lupus Erythematosus, Systemic; Male; Middle Aged; Polyethylene Glycols; Proportional Hazards Models; Ribavirin; Sustained Virologic Response; Taiwan; Viral Load |
顯示於: | 臨床醫學研究所 |
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