https://scholars.lib.ntu.edu.tw/handle/123456789/581842
標題: | The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C | 作者: | Younossi Z.M. Stepanova M. Henry L. Han K.-H. Ahn S.H. Lim Y.-S. Chuang W.-L. JIA-HORNG KAO Kinh N. Lai C.L. Yuen M.-F. Chan H.L.-Y. Lai W. |
關鍵字: | direct-acting antivirals; mental health; physical functioning; sofosbuvir; vitality | 公開日期: | 2018 | 出版社: | Blackwell Publishing Ltd | 卷: | 38 | 期: | 7 | 起(迄)頁: | 1179-1187 | 來源出版物: | Liver International | 摘要: | Background: Interferon (IFN)-based regimens cause significant impairment of health-related quality of life (HRQL). Hepatitis C virus (HCV) cure with IFN-free regimens improves HRQL. The effect of these regimens on HRQL in East Asian HCV patients is unclear due to lack of published evidence. Aim: To assess HRQL in East Asian HCV patients treated with an IFN-free regimen with sofosbuvir+ribavirin. Methods: Patients completed Short Form-36 (SF-36) before, during and after treatment. Results: 686 subjects were included (China: 56.7%; S. Korea: 18.8%; Taiwan: 12.7%; genotype 2: 40.8%; genotype 1: 29.6%; genotype 3: 18.4%; genotype 6: 11.2%; cirrhosis: 13.4%; treatment-na?ve: 66.5%). Patients received either pegylated-IFN, sofosbuvir, and ribavirin (IFN+SOF+RBV) for 12?weeks (n?=?155, genotypes 1 and 6) or SOF+RBV for 12-24?weeks (n?=?531, all genotypes). The SVR-12 rates were 95.5% and 96.0%; respectively (P?=.76). Baseline HRQL scores were similar between treatment groups (all P?>.05). By the end of treatment, the IFN-treated group experienced significant declines in most HRQL scores (on average, by up to ?13.3 points on a 0-100 scale from the baseline level, P?<.02) while subjects on SOF/RBV had milder impairments (up to ?5.4 points). Achieving SVR-12 was associated with HRQL improvement regardless of regimen (up to +2.9 points, P?<.05). The use of IFN-free treatment was a consistent independent predictor of higher HRQL scores during treatment (β: +2.1 to +10.7 points, P?<.02). Conclusions: East Asian HCV patients treated with an IFN-free regimen had better on-treatment HRQL scores. These data should inform policymakers about the comprehensive benefits of IFN-free regimens in East Asian patients with HCV. ? 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041042149&doi=10.1111%2fliv.13650&partnerID=40&md5=b8be06a4760c00d752d0f333ec4bccca https://scholars.lib.ntu.edu.tw/handle/123456789/581842 |
ISSN: | 1478-3223 | DOI: | 10.1111/liv.13650 | SDG/關鍵字: | peginterferon; ribavirin; sofosbuvir; antivirus agent; interferon; ribavirin; sofosbuvir; adult; antiviral therapy; Article; China; chronic hepatitis C; controlled clinical trial (topic); controlled study; East Asian; female; genotype; Hong Kong; human; major clinical study; male; multicenter study (topic); phase 3 clinical trial (topic); quality of life; Short Form 36; South Korea; Taiwan; Viet Nam; chronic hepatitis C; clinical trial; combination drug therapy; complication; Far East; genetics; Hepacivirus; liver cirrhosis; middle aged; multicenter study; phase 3 clinical trial; randomized controlled trial; severity of illness index; statistical model; sustained virologic response; time factor; Adult; Antiviral Agents; Drug Therapy, Combination; Far East; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Linear Models; Liver Cirrhosis; Male; Middle Aged; Quality of Life; Ribavirin; Severity of Illness Index; Sofosbuvir; Sustained Virologic Response; Time Factors |
顯示於: | 臨床醫學研究所 |
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