https://scholars.lib.ntu.edu.tw/handle/123456789/582001
Title: | Global perspective on the natural history of chronic hepatitis B: Role of hepatitis B virus genotypes A to J | Authors: | CHUN-JEN LIU JIA-HORNG KAO |
Issue Date: | 2013 | Journal Volume: | 33 | Journal Issue: | 2 | Start page/Pages: | 97-102 | Source: | Seminars in Liver Disease | Abstract: | Clinical outcomes of chronic hepatitis B virus (HBV) infection vary widely. In addition to host factors, several viral factors including HBV genotype, viral load, specific viral mutations and quantitative HBsAg levels, have been associated with disease outcomes. Among viral factors, HBV genotype correlates with not only the clinical outcomes, but also with the response to interferon treatment. Currently, 10 HBV genotypes have been identified. Compared with genotype A and B cases, patients with genotypes C and D have lower rates and usually delayed onset of spontaneous HBeAg seroconversion. HBV-genotype C has a higher frequency of basal core promoter (BCP) A1762T/G1764A mutation and preS deletion, and a higher viral load than genotype B. Similarly, genotype D has a higher prevalence of BCP A1762T/G1764A mutation than genotype A. These observations suggest pathogenic differences between HBV genotypes. Genotyping of HBV can help practicing physicians identify chronic hepatitis B patients at risk of disease progression. ? 2013 by Thieme Medical Publishers, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878868662&doi=10.1055%2fs-0033-1345716&partnerID=40&md5=4981d77dba03deab7749b20c2ee774d5 https://scholars.lib.ntu.edu.tw/handle/123456789/582001 |
ISSN: | 0272-8087 | DOI: | 10.1055/s-0033-1345716 | SDG/Keyword: | alanine aminotransferase; hepatitis B surface antigen; Africa; alanine aminotransferase blood level; alcohol consumption; chronicity; disease course; ethnic difference; Europe; family history; gene deletion; genotype; geographic distribution; hepatitis B; Hepatitis B virus; human; incidence; India; Japan; liver cell carcinoma; liver cirrhosis; liver fibrosis; prevalence; priority journal; review; seroconversion; Taiwan; United States; vaccination; vertical transmission; virus load; virus mutation; Animals; Antiviral Agents; Biological Markers; Carcinoma, Hepatocellular; Disease Progression; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Mutation; Phenotype; Treatment Outcome; Viral Load |
Appears in Collections: | 臨床醫學研究所 |
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