https://scholars.lib.ntu.edu.tw/handle/123456789/582201
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang S.-S. | en_US |
dc.contributor.author | Fu L.-S. | en_US |
dc.contributor.author | Chang C.-S. | en_US |
dc.contributor.author | Yeh H.-Z. | en_US |
dc.contributor.author | Chen G.-H. | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.date.accessioned | 2021-09-04T06:19:01Z | - |
dc.date.available | 2021-09-04T06:19:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750452743&doi=10.1111%2fj.1440-1746.2006.04677.x&partnerID=40&md5=31dbd4bf36ad604b3e9a2ec3d27cc10b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/582201 | - |
dc.description.abstract | Background: Clearance of hepatitis C virus (HCV) is attributed to host cellular immune responses, in which T helper cells play a critical role. The purpose of the present paper was therefore to study the serial changes of serum soluble markers released from T helper 1 (Th1) and 2 (Th2) and their correlations with treatment responses in chronic hepatitis C patients receiving interferon-α plus ribavirin for 24 weeks. Methods: Serum markers (soluble CD26 and CD30 levels) of T helper cells were quantified before and 6 months after combination therapy in 33 chronic hepatitis C patients and in 20 healthy controls. Results: Compared to healthy controls, chronic hepatitis C patients had significantly lower serum soluble CD26 levels before (140.4 ± 63.9 ng/mL vs 200.6 ± 60.3 ng/mL, P < 0.0001) and after (115.9 ± 32.9 ng/mL vs 200.6 ± 60.3 ng/mL, P < 0.0001) combination therapy. The level was even lower in those with non-sustained virologic response (non-SVR; 139.0 ± 50.9 ng/mL vs 117.7 ± 40.3 ng/mL, P = 0.039). In contrast, soluble CD30 levels at 6 months after combination therapy were significantly lower in patients with SVR than those with non-SVR (6.4 ± 3.5 U/mL vs 10.4 ± 5.4 U/mL, P = 0.021). Conclusion: Chronic hepatitis C patients have a weak Th1 response as reflected by lower soluble CD26 levels and the levels are even lower in non-sustained responders. In sharp contrast, downregulation of Th2 response with serial changes of soluble CD30 level is associated with successful treatment of HCV infection. ? 2006 The Authors. | - |
dc.publisher | Blackwell Publishing | - |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology (Australia) | - |
dc.subject | Chronic hepatitis; Hepatitis C virus; Interferon; Lymphocytes; Ribavirin; sCD26; sCD30; Th1/Th2 response | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alpha2b interferon; CD30 antigen; dipeptidyl peptidase IV; interferon; peginterferon; ribavirin; article; cellular immunity; clinical article; controlled study; drug dose regimen; drug response; genotype; helper cell; hepatitis C; host cell; human; immune response; priority journal; treatment response; virology | - |
dc.title | Changes of soluble CD26 and CD30 levels correlate with response to interferon plus ribavirin therapy in patients with chronic hepatitis C | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1440-1746.2006.04677.x | - |
dc.identifier.scopus | 2-s2.0-33750452743 | - |
dc.relation.pages | 1789-1793 | - |
dc.relation.journalvolume | 21 | - |
dc.relation.journalissue | 12 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床醫學研究所 |
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