https://scholars.lib.ntu.edu.tw/handle/123456789/582209
標題: | Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia | 作者: | JIA-HORNG KAO DING-SHINN CHEN |
關鍵字: | Disease burden; Genotype; HBV; HCV; Hepatocellular carcinoma; Screening | 公開日期: | 2005 | 卷: | 25 | 期: | 4 | 起(迄)頁: | 696-703 | 來源出版物: | Liver International | 摘要: | Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a marked difference in geographic distribution. More than 80% of HCC cases occur in developing countries, especially the Far East and Southeast Asia. Although immunization has been successful against hepatitis B virus (HBV), a changing disease burden of HCC has been observed in many parts of the world because of the increasing prevalence and duration of hepatitis C virus (HCV) infection in these countries. In addition, the age-specific incidence of HCC has progressively shifted toward younger people. Hepatitis B genotypes B and C are prevalent in the Far East and Southeast Asia, and the clinical relevance of HBV genotypes has become increasingly recognized. Compared with genotype C, genotype B is associated with earlier hepatitis B e antigen seroconversion, slower progression to cirrhosis and less frequent development of HCC. By using periodic examinations of serum alfa-fetoprotein levels and abdominal ultrasonography, small HCC can be detected and treated earlier. However, prevention of HBV and HCV infections as well as effective treatment of the chronic viral infections with timely interventions are still needed for the global control of HCC, particularly in the Far East and Southeast Asia. ? Blackwell Munksgaard 2005. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-22844447947&doi=10.1111%2fj.1478-3231.2005.01139.x&partnerID=40&md5=72c2655ad950eaf8f0fbfe1220747f2c https://scholars.lib.ntu.edu.tw/handle/123456789/582209 |
ISSN: | 1478-3223 | DOI: | 10.1111/j.1478-3231.2005.01139.x | SDG/關鍵字: | alpha fetoprotein; hepatitis B(e) antigen; adult; age distribution; aged; cancer control; cancer incidence; developing country; disease duration; echography; Far East; female; genotype; geographic distribution; hepatitis B; Hepatitis B virus; hepatitis C; human; immunization; infection prevention; liver cell carcinoma; liver cirrhosis; male; periodic medical examination; prevalence; review; seroconversion; sex ratio; Southeast Asia; Asia, Southeastern; Carcinoma, Hepatocellular; Early Diagnosis; Far East; Female; Hepatitis, Viral, Human; Humans; Liver Neoplasms; Male |
顯示於: | 臨床醫學研究所 |
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