https://scholars.lib.ntu.edu.tw/handle/123456789/582223
標題: | Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma | 作者: | YEN-HSUAN NI MEI-HWEI CHANG Wang K.-J. HONG-YUAN HSU HUEY-LING CHEN JIA-HORNG KAO Shiou-Hwei Yeh YUNG-MING JENG KEH-SUNG TSAI DING-SHINN CHEN |
公開日期: | 2004 | 出版社: | W.B. Saunders | 卷: | 127 | 期: | 6 | 起(迄)頁: | 1733-1738 | 來源出版物: | Gastroenterology | 摘要: | Background & Aims: The aim of this study was to investigate the influence of hepatitis B virus (HBV) genotypes on the clinical outcome of chronic childhood HBV infection and hepatocellular carcinoma (HCC). Methods: A total of 460 HBV carrier children were followed-up for 15 years and 26 children with HBV-related HCC were recruited. HBV genotyping was examined at enrollment and the latest follow-up of these carrier children and at diagnosis in HCC children. Viral load was checked at enrollment for the carrier children. These carriers were grouped based on their initial hepatitis B e antigen (HBeAg) and antibody to hepatitis B e antigen (anti-HBe) status. The HBeAg positive (+) group was divided further into an HBeAg(+/+) group and HBeAg(+/-) group, depending on whether spontaneous HBeAg seroconversion occurred during the follow-up period. Results: Genotype B constituted 73%, 86%, and 76% in the HBeAg(+/+), HBeAg(+/-), and anti-HBe(+) groups, respectively. Genotype C was found in 27%, 8%, and 6% in the HBeAg(+/+), HBeAg(+/-), and anti-HBe(+) group, respectively. Genotype C carriers were more prevalent in the HBeAg(+/+) group than the other 2 groups (P =. 01), and had a delayed HBeAg seroconversion compared with the genotype B carriers (P <. 001). Changes of genotype during the follow-up period were rare (2.8%). In those with HCC, genotype B was also the major type (74%). There was no difference in the baseline viral load between genotypes B and C. Conclusions: Although HBV genotype B dominates in children with chronic HBV infection and HCC in Taiwan, genotype C delays HBeAg seroconversion in pediatric chronic HBV infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-9644258636&doi=10.1053%2fj.gastro.2004.09.048&partnerID=40&md5=2e1ee9180c6a3ebf4fb15154483a056a https://scholars.lib.ntu.edu.tw/handle/123456789/582223 |
ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2004.09.048 | SDG/關鍵字: | hepatitis B(e) antibody; hepatitis B(e) antigen; article; child; childhood disease; chronic disease; controlled study; disease carrier; disease course; female; follow up; genotype; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; major clinical study; male; priority journal; seroconversion; superinfection; virus load; virus virulence |
顯示於: | 臨床醫學研究所 |
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