https://scholars.lib.ntu.edu.tw/handle/123456789/582380
標題: | Evaluating functional outcomes of botulinum toxin type a injection combined with occupational therapy in the upper limbs of children with cerebral palsy: A 9-month follow-up from the perspectives of both child and caregiver | 作者: | Lin Y.-C. CHIEN-YU HUANG Lin I.-L. JENG-YI SHIEH Chung Y.-T. Chen K.-L. |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 11 | 起(迄)頁: | e0142769 | 來源出版物: | PLoS ONE | 摘要: | Objective To assess the effectiveness of combining botulinum toxin type A (BoNT-A) with functional occupational therapy (OT) at 9-month follow-up in children with cerebral palsy (CP) with bilateral upper limb impairments from the perspectives of both child and caregiver. Methods Twelve children with CP and their caregivers were assessed across 5 time points over 9 months based on the ICF after BoNT-A injection and functional OT in this open-label study. Results Significant differences were found across the 5 time points (p < .05) for both grasp and visual-motor integration with small effects (effect sizes = 0.12-0.24) and the self-care capability and performance of social function (p < .05). However, based on the effect sizes (0.02-0.14), no significant effects were found at the 4 post-test time points. Small effects were found on the psychological domain (effect sizes = 0.25-0.37) and environmental domains (effect size = 0.27) at follow-ups. Conclusion Combining a BoNT-A injection with OT not only reduced the muscle tone and increased ROM but also improved the upper limb function and self-care capability in children with CP. More importantly, these effects persisted for up to 9 months. Functional OT extends the effectiveness of a BoNT-A injection. ? 2015 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957602068&doi=10.1371%2fjournal.pone.0142769&partnerID=40&md5=9268a34bd6d68948c793fb16db734782 https://scholars.lib.ntu.edu.tw/handle/123456789/582380 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0142769 | SDG/關鍵字: | botulinum toxin A; botulinum toxin A; arm disease; arm movement; Article; cerebral palsy; child; clinical article; clinical effectiveness; clinical trial; female; follow up; grip strength; human; male; muscle tone; occupational therapy; outcome assessment; prospective study; quality of life; range of motion; self care; social interaction; spasticity; treatment duration; visuomotor coordination; adult; caregiver; cerebral palsy; intramuscular drug administration; Muscle Spasticity; occupational therapy; pathology; preschool child; treatment outcome; upper limb; Adult; Botulinum Toxins, Type A; Caregivers; Cerebral Palsy; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Male; Muscle Spasticity; Occupational Therapy; Treatment Outcome; Upper Extremity |
顯示於: | 職能治療學系 |
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