https://scholars.lib.ntu.edu.tw/handle/123456789/582404
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wei, Ming Liang | en_US |
dc.contributor.author | YI-HUA LIAO | en_US |
dc.contributor.author | Weng, Wei Hung | en_US |
dc.contributor.author | Shih, Yuan Ta | en_US |
dc.contributor.author | YI-SHUAN SHEEN | en_US |
dc.contributor.author | CHI-KUANG SUN | en_US |
dc.date.accessioned | 2021-09-07T06:21:01Z | - |
dc.date.available | 2021-09-07T06:21:01Z | - |
dc.date.issued | 2021-07-01 | - |
dc.identifier.issn | 1077260X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/582404 | - |
dc.description.abstract | Melasma, which is thought to be associated with hyperactivation of melanocytes, is a common hyperpigmentary skin disorder. To treat this skin disorder, dermatologists can benefit from in vivo information of cellular morphometrics to evaluate pathologies of melasma and effectiveness of treatments. To acquire this useful information, we applied the in vivo slide-free label-free harmonic generation microscopy (HGM) to retrieve real-time HGM images and subsequent critical histopathological parameters. These in vivo quantitative parameters included melanin mass density (MMD), melanocyte dendricity score (MDS), melanophage density (MPD), and thickness of dermal papilla zone (DPZ). The statistical results from 33 recruited Asian female melasma patients showed that MMD, MDS, and MPD in melasma lesions were significantly higher than those in the surrounding normal skin; by contrast, the DPZ was lower. After treatment, the MMD, MPD, and DPZ restored toward the normal level; however, we observed no significant change of MDS. Our study indicates that these parameters are able to serve as clinical indices to evaluate the histopathological characteristics of melasma patients and the effectiveness of treatments. | en_US |
dc.relation.ispartof | IEEE Journal of Selected Topics in Quantum Electronics | en_US |
dc.subject | Harmonic generation microscopy (HGM) | in vivo melanocyte activity | melanin mass density (MMD) | melasma | en_US |
dc.title | A Study on Applying Slide-Free Label-Free Harmonic Generation Microscopy for Noninvasive Assessment of Melasma Treatments with Histopathological Parameters | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1109/JSTQE.2021.3069472 | - |
dc.identifier.scopus | 2-s2.0-85103775448 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/557112 | - |
dc.relation.journalvolume | 27 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.relation.pageend | 10 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Photonics and Optoelectronics | - |
crisitem.author.orcid | 0000-0002-4434-3780 | - |
crisitem.author.orcid | 0000-0002-8743-7496 | - |
crisitem.author.orcid | 0000-0002-4467-2509 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 醫學系 |
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