https://scholars.lib.ntu.edu.tw/handle/123456789/582425
標題: | Bullous pemphigoid with esophageal involvement presenting as exfoliative esophagitis and acute upper gastrointestinal bleeding: Reports of two cases and review of the literature | 作者: | WEI-HSIN WU CHIA-YU CHU |
公開日期: | 2008 | 卷: | 26 | 期: | 3 | 起(迄)頁: | 171-179 | 來源出版物: | Dermatologica Sinica | 摘要: | Bullous pemphigoid is the most common autoimmune blistering skin disease usually occurs in the elderly. The characteristic skin lesions present large and tense blisters arising on normal, erythematous, or urticarial bases and most commonly involve lower abdomen, inner thighs and flexural areas. The mucous membrane lesions occur in about 10 to 35 percent of patients and are almost limited to the oral mucous membrane. Esophageal involvement is a rare condition which may be completely asymptomatic or complicates with dysphagia and even life-threatening massive upper gastrointestinal bleeding. We present two cases of elderly patients with newly onset extensive bullous pemphigoid confirmed by pathological and immunofluorescence studies. One patient developed severe dysphagia. Endoscopy revealed diffuse exfoliative esophagitis and upper gastrointestinal hemorrhage; the other patient developed poor feeding and hematemesis aspirated from nasogastric tube and endoscopy showed multiple ulcers occurred on mid and lower esophagus. Both patients showed much improvement after systemic corticosteroid use. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-52149090331&partnerID=40&md5=4e399da066f7e5b271e8c0aa5be7f4a9 https://scholars.lib.ntu.edu.tw/handle/123456789/582425 |
ISSN: | 1027-8117 | SDG/關鍵字: | clobetasol propionate; corticosteroid; omeprazole; prednisolone; acute disease; adult; article; bullous pemphigoid; case report; disease severity; dysphagia; esophagitis; esophagus ulcer; exfoliative esophagitis; feeding; gastrointestinal endoscopy; hematemesis; histopathology; hospital admission; human; human tissue; immunofluorescence; low drug dose; male; nasogastric tube; skin biopsy; upper gastrointestinal bleeding |
顯示於: | 醫學系 |
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