https://scholars.lib.ntu.edu.tw/handle/123456789/582889
標題: | Early developmental nanoplastics exposure disturbs circadian rhythms associated with stress resistance decline and modulated by DAF-16 and PRDX-2 in C. elegans | 作者: | Yu, Chan Wei YI-CHUN WU VIVIAN LIAO |
關鍵字: | Caenorhabditis elegans | Circadian rhythms | DAF-16 | Nanoplastics | PRDX-2 | Stress resistance;Caenorhabditis elegans; Circadian rhythms; DAF-16; Nanoplastics; PRDX-2; Stress resistance | 公開日期: | 5-二月-2022 | 出版社: | Elsevier B.V. | 卷: | 423 | 期: | Art. No.127091 | 來源出版物: | Journal of Hazardous Materials | 摘要: | Plastics pollution is an emerging environmental problem and nanoplastics (NPs) toxicity has received great concern. This study investigated whether early developmental exposure to polystyrene NPs influence the circadian rhythms and the possible underlying mechanisms in C. elegans. We show that early developmental NPs exposure disturbs circadian rhythms in C. elegans and ASH neurons and G protein-coupled receptor kinase (GRK-2) are involved in the level of chemotaxis response. A higher bioconcentration factor in entrained worms was observed, suggesting that circadian interference results in increased NPs bioaccumulation in C. elegans. In addition, we show that reactive oxygen species produced by NPs exposure and peroxiredoxin-2 (PRDX-2) are related to the disturbed circadian rhythms. We further show that the NPs-induced circadian rhythms disruption is associated with stress resistance decline and modulated by transcription DAF-16/FOXO signaling. Because circadian rhythms are found in most living organisms and the fact that DAF-16 and PRDX-2 are evolutionarily conserved, our findings suggest a possible negative impact of NPs on circadian rhythms and stress resistance in higher organisms including humans. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/582889 | ISSN: | 03043894 | DOI: | 10.1016/j.jhazmat.2021.127091 | SDG/關鍵字: | Bioaccumulation; Caenorhabditis elegans; Circadian rhythms; DAF-16; Elegans; Environmental problems; G-protein-coupled receptor kinase; Nanoplastics; Peroxiredoxin-2; Plastic pollutions; Stress resistance; Biochemistry; G protein coupled receptor kinase 2 |
顯示於: | 分子與細胞生物學研究所 |
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