https://scholars.lib.ntu.edu.tw/handle/123456789/583147
標題: | Clinical characteristics of bacteraemia caused by Lactobacillus spp. and antimicrobial susceptibilities of the isolates at a medical centre in Taiwan, 2000-2014 | 作者: | MENG-RUI LEE Tsai C.-J. SHENG-KAI LIANG CHING-KAI LIN YU-TSUNG HUANG PO-REN HSUEH |
公開日期: | 2015 | 出版社: | Elsevier B.V. | 卷: | 46 | 期: | 4 | 起(迄)頁: | 439-445 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | The clinical characteristics of 89 patients with Lactobacillus bacteraemia treated at a university-affiliated hospital in northern Taiwan during 2000-2014 were retrospectively evaluated. Lactobacillus spp. were identified by 16S rRNA sequencing analysis and matrix-assisted laser desorption/ionisation time-of-flightmass spectrometry (MALDI-TOF/MS). Antimicrobial susceptibilities of the isolates were determined by broth microdilution. The most commonly isolated species was Lactobacillus salivarius (n = 21), followed by Lactobacillus paracasei (n = 16) and Lactobacillus fermentum (n = 13). Excluding three isolates with lower16S rRNA sequence similarity, MALDI-TOF/MS provided correct identification for 84.9% (73/86) of Lac-tobacillus isolates. Concordant identification was lowest for Lactobacillus casei (11%). The main infection foci were intra-abdominal infection (49%) and catheter-related bloodstream infection (17%). Only one-half of the patients received adequate antibiotic treatment during the bacteraemic episode. The majorityof patients with Lactobacillus bacteraemia were immune compromised. The 7-day and in-hospital mortality rates were 21% and 62%, respectively, and underlying malignancy was associated with a higher in-hospital mortality rate (odds ratio = 2.666). There were no significant differences in mortality (7-day,14-day, 30-day and in-hospital) among patients with bacteraemia due to different Lactobacillus spp. Minimum inhibitory concentrations were highest for glycopeptides, cephalosporins and fluoroquinolones and were lowest for carbapenems and aminopenicillins. Lactobacillus bacteraemia was associated with a high mortality rate, and patient outcome was associated with underlying malignancy. MALDI-TOF/MSwas able to accurately identify 84.9% of the Lactobacillus isolates, and L. salivarius was the predominant pathogen. The accuracy rate for identification of Lactobacillus spp. by MALDI-TOF/MS was lowest for L.casei. ? 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948564759&doi=10.1016%2fj.ijantimicag.2015.06.017&partnerID=40&md5=88a06f0d581cf97ab0caa0b1737787c6 https://scholars.lib.ntu.edu.tw/handle/123456789/583147 |
ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2015.06.017 | SDG/關鍵字: | amoxicillin plus clavulanic acid; bacterial RNA; carbapenem derivative; cefepime; ceftazidime; clindamycin; metronidazole; penicillin derivative; piperacillin plus tazobactam; quinoline derived antiinfective agent; ribosome RNA; teicoplanin; vancomycin; antiinfective agent; bacterial DNA; ribosome DNA; RNA 16S; abdominal infection; adult; antibiotic sensitivity; antibiotic therapy; Article; bacteremia; bacterium identification; bacterium isolate; broth dilution; catheter infection; disease association; female; human; immune deficiency; Lactobacillus; Lactobacillus casei; Lactobacillus fermentum; Lactobacillus paracasei; Lactobacillus rhamnosus; Lactobacillus salivarius; major clinical study; male; matrix assisted laser desorption ionization time of flight mass spectrometry; minimum inhibitory concentration; mortality; neoplasm; priority journal; prognosis; retrospective study; RNA sequence; sequence homology; Taiwan; aged; bacteremia; chemistry; classification; DNA sequence; drug effects; genetics; isolation and purification; Lactobacillus; mass spectrometry; microbial sensitivity test; microbiology; middle aged; pathology; survival analysis; university hospital; very elderly; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; DNA, Bacterial; DNA, Ribosomal; Female; Hospitals, University; Humans; Lactobacillus; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Survival Analysis; Taiwan |
顯示於: | 醫學系 |
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