https://scholars.lib.ntu.edu.tw/handle/123456789/584539
標題: | Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in localized prostate cancer | 作者: | Chen C.-S. CHAO-YUAN HUANG Huang S.-P. Lin V.C. Yu C.-C. Chang T.-Y. Bao B.-Y. |
關鍵字: | Biochemical recurrence; Prostate cancer; Radical prostatectomy; Single-nucleotide polymorphism; TCF7L2; Wnt pathway | 公開日期: | 2015 | 出版社: | Ivyspring International Publisher | 卷: | 12 | 期: | 3 | 起(迄)頁: | 243-247 | 來源出版物: | International Journal of Medical Sciences | 摘要: | Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer. Methods: We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across TCF7L2, and genotyped in 458 localized prostate cancer patients treated with radical prostatectomy (RP). Kaplan-Meier analysis, Cox proportional hazard model, and survival tree analyses were performed to identify significant SNPs that correlated with biochemical recurrence (BCR) after surgery. Results: A higher-order SNP-SNP interaction profile consisting of TCF7L2 rs7094463, rs10749127, and rs11196224 was significantly associated with BCR (Ptrend= 0.001). After adjusting for possible confounders, the genetic profile remained significant (Ptrend= 0.007). None of the studied SNPs were individually associated with BCR. Conclusions: Our results support a genetic interaction in the TCF7L2 SNPs as a predictor of disease recurrence after curative RP in localized prostate cancer patients. ? 2015 Ivyspring International Publisher. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922994270&doi=10.7150%2fijms.10953&partnerID=40&md5=ef7b5c551827c75699e34468ec67f34b https://scholars.lib.ntu.edu.tw/handle/123456789/584539 |
ISSN: | 1449-1907 | DOI: | 10.7150/ijms.10953 | SDG/關鍵字: | transcription factor 7 like 2; TCF7L2 protein, human; transcription factor 7 like 2; adult; aged; Article; biochemical recurrence free survival; cancer prognosis; cancer recurrence; gene; gene expression; gene interaction; genetic association; genetic variability; genotype; human; major clinical study; male; prostate cancer; prostatectomy; single nucleotide polymorphism; Taiwanese; TCF7L2 gene; disease free survival; genetics; Kaplan Meier method; middle aged; pathology; prognosis; Prostatic Neoplasms; tumor recurrence; Wnt signaling pathway; Aged; Disease-Free Survival; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathway |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。