https://scholars.lib.ntu.edu.tw/handle/123456789/584719
標題: | Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3 | 作者: | CHAO YUAN HUANG Lin, Chen-Si Tai, Wei-Tien Hsieh, Chi-Ying Shiau, Chung-Wai ANN-LII CHENG Chen, Kuen-Feng |
公開日期: | 1-七月-2013 | 卷: | 86 | 期: | 3 | 來源出版物: | International journal of radiation oncology, biology, physics | 摘要: | Hepatocellular carcinoma (HCC) is one of the most common and lethal human malignancies. Lack of efficient therapy for advanced HCC is a pressing problem worldwide. This study aimed to determine the efficacy and mechanism of combined sorafenib and radiation therapy treatment for HCC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/584719 | ISSN: | 03603016 | DOI: | 10.1016/j.ijrobp.2013.01.025 | SDG/關鍵字: | Cell culture; Cell death; Cells; Cytology; Drug products; Enzyme inhibition; Radiotherapy; Signal transduction; Ectopic expressions; Hepatocellular carcinoma; Human malignancies; Methods and materials; Radiation resistance; Radiation therapy treatment; Radiation-induced apoptosis; Signaling pathways; Radiation; caspase 9; cyclin D1; mitogen activated protein kinase 1; mitogen activated protein kinase 3; protein BAD; protein Bax; protein mcl 1; sorafenib; STAT3 protein; survivin; antineoplastic agent; BIRC5 protein, human; carbanilamide derivative; cyclin D1; drug derivative; inhibitor of apoptosis protein; myeloid cell leukemia sequence 1 protein; nicotinamide; protein bcl 2; sorafenib; STAT3 protein; tumor protein; animal experiment; animal model; apoptosis; article; cancer growth; cancer resistance; cell culture; colony formation; controlled study; down regulation; drug efficacy; drug mechanism; G2 phase cell cycle checkpoint; genetic transfection; human; human cell; human tissue; in vitro study; in vivo study; ionizing radiation; liver cell carcinoma; mouse; nonhuman; priority journal; protein expression; radiation induced apoptosis; radiosensitivity; RNA interference; signal transduction; Western blotting; chemoradiotherapy; drug antagonism; drug effect; liver cell carcinoma; liver tumor; methodology; physiology; radiation dose; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Chemoradiotherapy; Cyclin D1; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; RNA Interference; STAT3 Transcription Factor |
顯示於: | 醫學系 |
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