https://scholars.lib.ntu.edu.tw/handle/123456789/585102
標題: | Zearalenone Induces Dopaminergic Neurodegeneration via DRP-1-Involved Mitochondrial Fragmentation and Apoptosis in a Caenorhabditis elegans Parkinson's Disease Model | 作者: | CHIA-CHENG WEI Yang, Nien-Chieh Huang, Chi-Wei |
關鍵字: | Caenorhabditis elegans; DRP-1; Parkinson’s disease; dopaminergic neuron; mitochondrial dysfunction; zearalenone | 公開日期: | 13-十月-2021 | 卷: | 69 | 期: | 40 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | The contamination of mycotoxin zearalenone (ZEN) in foods has been reported worldwide, resulting in potential risks to food safety. However, the toxic mechanism of ZEN on neurodegenerative diseases has not been fully elucidated. Therefore, this study conducted in vivo ZEN neurotoxicity assessment on Parkinson's disease (PD)-related dopaminergic neurodegeneration and mitochondrial dysfunction using Caenorhabditis elegans. The results demonstrated that dopaminergic neuron damage was induced by ZEN exposure (1.25, 10, and 50 μM), and dopaminergic neuron-related behaviors were adversely affected subsequently. Additionally, the mitochondrial fragmentation was significantly increased by ZEN exposure. Moreover, upregulated expression of mitochondrial fission and cell apoptosis-related genes (drp-1, egl-1, ced-4, and ced-3) revealed the crucial role of DRP-1 on ZEN-induced neurotoxicity, which was further confirmed by drp-1 mutant and RNAi assays. In conclusion, our study indicates ZEN-induced dopaminergic neurodegeneration via DRP-1-involved mitochondrial fragmentation and apoptosis, which might cause harmful effects on PD-related symptoms. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/585102 | ISSN: | 0021-8561 1520-5118 |
DOI: | 10.1021/acs.jafc.1c05836 |
顯示於: | 食品安全與健康研究所 |
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